DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and SLC7A3

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001041629.1	Gene:	SLC7A3 / 84889	HGNCID:	11061	Length:	619	Species:	Homo sapiens

Alignment Length:	596	Identity:	286/596 - (47%)
Similarity:	400/596 - (67%)	Gaps:	40/596 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKA-------LTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVT 62
            |:|       |.||:|.:....|::|||.|:..||.|||||||||.|||||||:||.:.|||::.
Human     3 WQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIV 67

  Fly    63 ISFLIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGL 127
            |.||:||::|..||:|||||.||||::||||:|||||:||..|||.||||||.||||||||||..
Human    68 ICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAW 132

  Fly   128 SGYFDSLINNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVN 191
            |..||:||.|::||.|..|:.:.| ..|.:||||.:.|:||||..:||.||.||:.:..:||.||
Human   133 SSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197

  Fly   192 LVTIAIVLVAGAMNANVDNWRIPKKDVPEG------------FGTGGFMPFGIAGVMAGAAKCFY 244
            |:.:..|:::|.:..:|.||::.::|....            .|:|||:|||..|::.|||.|||
Human   198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262

  Fly   245 GFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDS 309
            .||||||||||||||.||:|:||:.||:||.:.||:||.||:.||:|:|||:...::|.|.||..
Human   263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLY 327

  Fly   310 VEWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGI 374
            :.|...:::|.:|::.||.|||||:|||:||::|||.:||:||:.|:.:::.|:||::||:||||
Human   328 IGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGI 392

  Fly   375 FASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKL---VSVKAPNVFRQ----- 431
            .|:.||.||.|..|||:|||||||||::|:||||:||||.::.||.   |.::...:..:
Human   393 IAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLT 457

  Fly   432 ----FFNGNSFREPNS-----MTSSITKVGIVVFAIFCLVWCSLQKVFDLDSTGGIVALSLVGAV 487
                ||..||...|.|     :.||:..|.:....:....|.......||..|..:|.|.|   :
Human   458 LWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLL---L 519

  Fly   488 LILICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFCY 552
            :|.|.|||..||.|:..|.||||.:|.:|.:|:|.|:|||.|:...||.||.:|::||:.|||.|
Human   520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGY 584

  Fly   553 GMRNSTQISRS 563
            |:::|.:..:|
Human   585 GIQHSLEEIKS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	282/578 (49%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	25/49 (51%)
SLC7A3	NP_001041629.1	2A0303	9..591	CDD:273330	283/584 (48%)
SLC7A3	NP_001041629.1	AA_permease_C	539..589	CDD:290617	25/49 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157299
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1172
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8495
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.790