DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Slc7a8

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_445894.1	Gene:	Slc7a8 / 84551	RGDID:	619904	Length:	533	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	108/517 - (20%)
Similarity:	204/517 - (39%)	Gaps:	67/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVT-ISFLIAAIASAFAGICYAEF 82
            |...|.:.:.|.....:.||:.:|.|::|....|..|.....:. |.:::..:.:|...:||||.
  Rat    33 GGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGVITAVGALCYAEL 97

  Fly    83 AARVPKAGSAYVYSYVTIGEFVAFTIGWNLILE-YVIGTASVARGLSGYFDSLINNNMSKALNES 146
            ...:||:|..|.|.....|....|...|..:|. |....|.:|...|.|.
  Rat    98 GVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYV--------------- 147

  Fly   147 MHIDVDFLGDYPD-----FLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIVLVAGAMNA 206
              :...|...:|.     .|:...:|||..:.....:.::.:.:|||...|:.:|::::.|.:..
  Rat   148 --LQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGVVQI 210

  Fly   207 NVDN--WRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGEEAINPKRNIPLS 269
            ....  |..| |:..|.|.........:|.:....|   ||  |::.:....||.::|.:|:|.:
  Rat   211 CKGEFFWLEP-KNAFENFQEPDIGLVALAFLQGSFA---YG--GWNFLNYVTEELVDPYKNLPRA 269

  Fly   270 IVVSL-IIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKWIVTIGAVFALCTSLLG 333
            |.:|: ::.|:..|.....:|.|.|......:| ....|.......:.||:.|....:....:.|
  Rat   270 IFISIPLVTFVYVFANIAYVTAMSPQELLASNA-VAVTFGEKLLGVMAWIMPISVALSTFGGVNG 333

  Fly   334 AMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLDQLVDMMSIGTLL 398
            ::|...|:.:|..::|.|...|:.::....||:.|.:.:.:...:|.:..::..|::.:.....|
  Rat   334 SLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYL 398

  Fly   399 AYTIVAICVLVLRYQDEEMTKLVSVKAPNVFRQFFNGNSFREPNSMTSSITKVGIVVFAIFCLVW 463
            .|.:.....:|||:           |.|::.|..                 |:.::...|:.|.|
  Rat   399 FYGVTVAGQIVLRW-----------KKPDIPRPI-----------------KISLLFPIIYLLFW 435

  Fly   464 CSLQKVFDLDS---TGGI-VALSLVGAVLILICVVIGMQPVSTIELTFKVPLVPFVPCLSVF 521
            ..| .:|.|.|   ..|| :|:.|.|..:..:.|....:|....:....:.||....|:.|:
  Rat   436 AFL-LIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFNDFIESLTLVSQKMCVVVY 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	108/517 (21%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	4/15 (27%)
Slc7a8	NP_445894.1	2A0308	1..499	CDD:273332	108/517 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		108/517 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..533
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940