Protein Alignment slif and SLC7A4

DIOPT Version :9

• Sequence 1: NP_649428.1
• Gene: slif / 40510
• FlyBaseID: FBgn0037203
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_004164.2
• Gene: SLC7A4 / 6545
• HGNCID: 11062
• Length: 635
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 245/645 - (37%)
• Similarity: 363/645 - (56%)
• Gaps: 84/645 - (13%)

  Fly     1 MTNLWKALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISF 65
            :..|.:.|.|.|..:.:..|:.|.|.|:..|||.||||..:|.|:|||.|.||..:|||||.:||
Human    11 LARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSF 75

  Fly    66 LIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGY 130
            .:||:||..|.:|||||.||||:.||||:::||::||..||.||||::|||:||.|:|||..|||
Human    76 GVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGY 140

  Fly   131 FDSLINNNMSKALNESMHI---DVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNL 192
            .||:.:::: :...|: |:   .|..||.|||||:.|::||.:|.::.||:.||:||:.|:.::|
Human   141 LDSMFSHSI-RNFTET-HVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISL 203

  Fly   193 VTIAIVLVAGAMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGE 257
            :.|..:::.|.:.|...||...:         |||.|||.:|||||.|.|||.|||||.||.:.|
Human   204 LVILFIVILGFILAQPHNWSADE---------GGFAPFGFSGVMAGTASCFYAFVGFDVIAASSE 259

  Fly   258 EAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKWIVTIG 322
            ||.||:|::||:|.:||.|...:|..||||||:|:|::..|.|:....||....:....:||..|
Human   260 EAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAG 324

  Fly   323 AVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLDQ 387
            ::.|:.|.||..:|.||||:|||..||:.|:..:.|:..|:.|:..|:..|:..:.:|:|.:|:.
Human   325 SICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLES 389

  Fly   388 LVDMMSIGTLLAYTIVAICVLVLRYQDEE------------MTK----------LV-----SVKA 425
            ||..:|:|||||||.||..::|||:|...            :||          ||     ||..
Human   390 LVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPE 454

  Fly   426 PNVFRQ-------FFNGNSFREPNS---------MTSSITKVGIVVFAIFCLVWCSLQKVFDLDS 474
            |...:.       |.:|.|   |.:         :.|:||...::||.         .....|..
Human   455 PGELKPALRPYLGFLDGYS---PGAVVTWALGVMLASAITIGCVLVFG---------NSTLHLPH 507

  Fly   475 TGGIVALSLVGAVLILICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFL 539
            .|.|:.|.|...:.:|..:|:|.......|..|::|:||.:|.||:..|:.||.:|...||:||.
Human   508 WGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFS 572

  Fly   540 IWIVIGYVIYFCYGMRNSTQISRS-------------RSHAEVAASALQ--NQGQHVNPG 584
            ||:::|..:||.||:|:|.:..|.             |...|....|:|  :|....:||
Human   573 IWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVFPRGSLEETVQAMQPPSQAPAQDPG 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	235/594 (40%)
		AA_permease_C	507..557	CDD:290617	23/49 (47%)
SLC7A4	NP_004164.2	2A0303	26..592	CDD:273330	233/588 (40%)
		AA_permease_C	540..590	CDD:290617	23/49 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.680