Protein Alignment slif and SLC7A2

DIOPT Version :9

• Sequence 1: NP_649428.1
• Gene: slif / 40510
• FlyBaseID: FBgn0037203
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001158243.1
• Gene: SLC7A2 / 6542
• HGNCID: 11060
• Length: 698
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 291/650 - (44%)
• Similarity: 405/650 - (62%)
• Gaps: 59/650 - (9%)

  Fly     6 KALTRRK--TEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIA 68
            :.|.|||  |.|..| :::|.|.|:..||.|||||||||.|||||||:||...:||::.:|||||
Human    52 RCLIRRKIVTLDSLE-DTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIA 115

  Fly    69 AIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDS 133
            |:||..||:|||||.|||||.||||:|:|||:||..||..||||||.|||||:||||..||.||.
Human   116 ALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE 180

  Fly   134 LINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIV 198
            |::..:.:.|.....::...|.:||||.:..::||||.:|:||.|||:::|.:||.||::.:..|
Human   181 LLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFV 245

  Fly   199 LVAGAMNANVDNWRI---------------PKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVG 248
            :|||.:..||.||:|               |.::....:|.|||||:|..|.:||||.|||.|||
Human   246 MVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVG 310

  Fly   249 FDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWY 313
            ||||||||||..||::.||:.||.||::.|::|||||..||:|:|||..|:.:|.|.||:.|.|.
Human   311 FDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWG 375

  Fly   314 TIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASI 378
            ..|::|..|::.||.|||||::||:||::|||.:||:|||.|:.:||.||||::||:.||..|::
Human   376 PAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAL 440

  Fly   379 MAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQ-----DE-----------EMTKLVSVKAPN 427
            ||.||:|..||||||||||:||::||.|||:||||     |:           ...::.|.....
Human   441 MAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQ 505

  Fly   428 VFRQFFNGNSFRE-------PNSMTSSITKVGIVVFAIFCLVWCSLQKVFDLDSTGGIVALSLVG 485
            |......|.|.|.       |...::|:... :|.|..|.::..|:...:.:.:...:.|.||..
Human   506 VTMLQRQGFSMRTLFCPSLLPTQQSASLVSF-LVGFLAFLVLGLSVLTTYGVHAITRLEAWSLAL 569

  Fly   486 AVLILICVV-----IGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIG 545
            ..|.|:..|     |..||.:..::.|.||.:||:|..|:..|:|||.||..:||:||.||:.||
Human   570 LALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIG 634

  Fly   546 YVIYFCYGMRNSTQ-ISRSRSHAE------VAASALQNQGQHVNPGFEPDYKVENGGRPYEFSEK 603
            ::|||.||:|:|.: ..|..::.|      |.|:|.:......|     |:...|...|:.|.||
Human   635 FLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQAN-----DHHPRNLSSPFIFHEK 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	278/593 (47%)
		AA_permease_C	507..557	CDD:290617	27/49 (55%)
SLC7A2	NP_001158243.1	2A0303	45..648	CDD:273330	279/597 (47%)
		AA_permease_C	596..646	CDD:290617	27/49 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157252
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1172
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8495
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840