Protein Alignment slif and SLC7A1

DIOPT Version :10

• Sequence 1: NP_649428.1
• Gene: slif / 40510
• FlyBaseID: FBgn0037203
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_003036.1
• Gene: SLC7A1 / 6541
• HGNCID: 11057
• Length: 629
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 282/630 - (44%)
• Similarity: 388/630 - (61%)
• Gaps: 80/630 - (12%)

  Fly     1 MTNLWKALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISF 65
            :.|:.:.:.|||..|.:..|::|:|.||.|||.|||||||||.|||||||.||...||||:.|||
Human     6 LLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISF 70

  Fly    66 LIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGY 130
            ||||:||..||:||.||.|||||.||||:|||||:||..||..||||||.|:|||:||||..|..
Human    71 LIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSAT 135

  Fly   131 FDSLINNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVT 194
            ||.||...:.:.....|.::. ..|.:.||..:..::|:|..:|..|.|||:.:|.|||.:|::.
Human   136 FDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLV 200

  Fly   195 IAIVLVAGAMNANVDNWRIPKK-------------DVPEGF-GTGGFMPFGIAGVMAGAAKCFYG 245
            :..::|:|.:..:|.||::.::             |..||. |.|||||||.:||::|||.|||.
Human   201 LGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYA 265

  Fly   246 FVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSV 310
            |||||||||||||..||::.||:.||.||:|.|::|||||..||:|:||:..|.::|.|.||..|
Human   266 FVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHV 330

  Fly   311 EWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIF 375
            .|...|:.|.:|::.||..||||:|||:||::|||.:||:|||.|:.||..||||::||:.||..
Human   331 GWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAV 395

  Fly   376 ASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDE------------------------- 415
            |::||.||:|..|||:|||||||||::||.||||||||.|
Human   396 AAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELAS 460

  Fly   416 ------------EMTKLVSVKAPNVFRQFFNGNSFREPNSMTSSITKVGIVVFAIFCLVWC---- 464
                        ||..|.::.:|...          ||:.::..|..:...:.|:..:.:|
Human   461 TNDSQLGFLPEAEMFSLKTILSPKNM----------EPSKISGLIVNISTSLIAVLIITFCIVTV 515

  Fly   465 ----SLQKVFDLDSTGGIVALSLVGAVLILICVVIGM---QPVSTIELTFKVPLVPFVPCLSVFA 522
                :|.|       |.:.|:.|:....:|..||.|:   ||.|..:|:||||.:|.:|.||:|.
Human   516 LGREALTK-------GALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFV 573

  Fly   523 NLYLMFQLDLNTWIRFLIWIVIGYVIYFCYGMRNSTQISRSRSHA 567
            |:|||.|||..||:||.:|::||::|||.||:.:|.:.|.....|
Human   574 NVYLMMQLDQGTWVRFAVWMLIGFIIYFGYGLWHSEEASLDADQA 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	278/611 (45%)
SLC7A1	NP_003036.1	2A0303	4..610	CDD:273330	280/620 (45%)