Protein Alignment slif and SLC7A1

DIOPT Version :9

• Sequence 1: NP_649428.1
• Gene: slif / 40510
• FlyBaseID: FBgn0037203
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_016876202.1
• Gene: SLC7A1 / 6541
• HGNCID: 11057
• Length: 643
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 267/653 - (40%)
• Similarity: 367/653 - (56%)
• Gaps: 118/653 - (18%)

  Fly     1 MTNLWKALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISF 65
            :.|:.:.:.|||..|.:..|::|:|.||.|||.|||||||||.|||||||.||...||||:.|||
Human     6 LLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISF 70

  Fly    66 LIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGY 130
            ||||:||..||:||.||.|||||.||||:|||||:||..||..||||||.|:|||:||||..|..
Human    71 LIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSAT 135

  Fly   131 FDSLINNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVT 194
            ||.||...:.:.....|.::. ..|.:.||..:..::|:|..:|..|.|||:.:|.|||.:|::.
Human   136 FDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLV 200

  Fly   195 IAIVLVAGAMNANVDNWRIPKK-------------DVPEGF-GTGGFMPFGIAGVMAGAAKCFYG 245
            :..::|:|.:..:|.||::.::             |..||. |.|||||||.:||::|||.|||.
Human   201 LGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYA 265

  Fly   246 FVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSV 310
            |||||||||||||..||::.||:.||.||:|.|::|||||..||:|:||:..|.::|.|.||..|
Human   266 FVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHV 330

  Fly   311 EWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIF 375
            .|...|:.|.:|::.||..||||:|||:||::|||.:||:|||.|:.||..||||::||:.||..
Human   331 GWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAV 395

  Fly   376 ASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDE------------------------- 415
            |::||.||:|..|||:|||||||||::||.||||||||.|
Human   396 AAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELAS 460

  Fly   416 ------------EMTKLVSVKAPNVFRQFFNGNSFREPNSMTSSITKVGIVVFAIFCLVWC---- 464
                        ||..|.::.:|...          ||:.::..|..:...:.|:..:.:|
Human   461 TNDSQLGFLPEAEMFSLKTILSPKNM----------EPSKISGLIVNISTSLIAVLIITFCIVTV 515

  Fly   465 ----SLQKVFDLDSTGGIVALSLVGAVLILICVVIGM---QPVSTIELTFKVPLVPFVPCLSVFA 522
                :|.|       |.:.|:.|:....:|..||.|:   ||.|..:|:||..|
Human   516 LGREALTK-------GALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKTVL----------- 562

  Fly   523 NLYLMFQLDLNTWIRFLIWIVIGYVIYFCYGMR----NSTQISRSRSHAEVAASALQNQGQ---H 580
                     ||.|.|           ..|:|::    :|..:..|..|.|.....|.:...   |
Human   563 ---------LNYWNR-----------RHCHGLKPPPVSSGSLPASAPHPEHLRERLSHDAAGPGH 607

  Fly   581 VNP 583
            :.|
Human   608 LGP 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	259/615 (42%)
		AA_permease_C	507..557	CDD:290617	9/53 (17%)
SLC7A1	XP_016876202.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157302
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1172
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8495
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840