DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and Slc7a2

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001128158.1	Gene:	Slc7a2 / 64554	RGDID:	68387	Length:	658	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	291/653 - (44%)
Similarity:	403/653 - (61%)	Gaps:	65/653 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KALTRRK--TEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIA 68
            :.|.|||  |.|..| :|:|.|.|...||.|||||||||.|||||||:||...:||::.:|||||
  Rat    12 RCLIRRKIVTLDSLE-DSKLCRCLTTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIA 75

  Fly    69 AIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDS 133
            |:||..||:|||||.|||||.||||:|:|||:||..||..||||||.|||||:||||..||.||.
  Rat    76 ALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE 140

  Fly   134 LINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIV 198
            |:|..:.:.......::...|.:||||.:..:|||||.:|:||.|||:::|..||.:|::.:..|
  Rat   141 LLNKQIGQFFKTYFKMNYTGLAEYPDFFAVCLVLLLAGLLSFGVKESAWVNKFFTAINILVLLFV 205

  Fly   199 LVAGAMNANVDNWRI---------------PKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVG 248
            :|||.:..||.||:|               |.::....:|.|||||:|..|.:||||.|||.|||
  Rat   206 MVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVG 270

  Fly   249 FDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWY 313
            ||||||||||..||::.||:.||.||::.|::|||||..||:|:|||..|:.:|.|.||:.|.|.
  Rat   271 FDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWG 335

  Fly   314 TIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASI 378
            ..|::|..|::.||.|||||::||:||::|||.:||:|||.|:.:||.||||::||:.||..|::
  Rat   336 PAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAAV 400

  Fly   379 MAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQD----------------EEMTKLVSVKAPN 427
            ||.||:|..||||||||||:||::||.|||:||||.                |..|...|.....
  Rat   401 MAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLCYEQPKYTPEKDILESCTNATSKSESQ 465

  Fly   428 V---------FRQFFNGNSFREPNSMTSSITKVGIVVFAIFCLVWCSLQKVFDLDSTGGIVALSL 483
            |         .|..||.::.  |...::|:... :|.|..|.:...|:...:.:.:...:.|.||
  Rat   466 VTMLQGQGFSLRTLFNPSAL--PTRQSASLVSF-LVGFLAFLIAGLSILTTYGVQAIARLEAWSL 527

  Fly   484 -VGAVLILIC----VVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIV 543
             :.|:.:::|    :.|..||.:..::.|.||.:||:|..|:..|:|||.||..:||:||.||:|
  Rat   528 ALLALFLVLCAAVILTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMV 592

  Fly   544 IGYVIYFCYGMRNSTQISRSRSHAE--------VAASALQNQGQHVNPGFEPDYKVENGGRPYEF 600
            :|::|||.||:|:|.: ...|...|        |.|:|.:......|     |:...|...|:..
  Rat   593 LGFLIYFAYGIRHSLE-GNPRDEEEDEDVCPDNVNAAAEEKSAMQAN-----DHHQRNLSLPFIL 651

  Fly   601 SEK 603
            .||
  Rat   652 HEK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	279/595 (47%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	27/49 (55%)
Slc7a2	NP_001128158.1	2A0303	5..608	CDD:273330	280/599 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351190
Domainoid	1	1.000	457	1.000	Domainoid score	I470
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1161
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8968
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910