DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and SLC7A14

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_066000.2	Gene:	SLC7A14 / 57709	HGNCID:	29326	Length:	771	Species:	Homo sapiens

Alignment Length:	704	Identity:	261/704 - (37%)
Similarity:	374/704 - (53%)	Gaps:	136/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KALTRRKTEDVNEGE-------SQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTI 63
            :.|..:..|.:.||.       ::||:||...||.:|||||.:|.|:||::|.||..:|||.|.:
Human    25 RILRTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIV 89

  Fly    64 SFLIAAIASAFAGICYAEFAARVPK-AGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGL 127
            ||:|||:||..:|:|||||..|||| .||||.|||||:||||||.|||||||||:||||:.|..|
Human    90 SFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASAL 154

  Fly   128 SGYFDSLINNNMSKALNESMHIDVDFLG----DYPDFLSFGMVLLLAAILAFGAKESSFLNNIFT 188
            |..||||.|:.:|:.:.:|:. .::.||    .|||.|:..:.:::..|:|.|.|.|...||:..
Human   155 SSMFDSLANHTISRWMADSVG-TLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLN 218

  Fly   189 TVNLVTIAIVLVAGAMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIA 253
            .:||.....:::||....|...|           ..|.|:|.|.:||:.|||.|||.|:|||.||
Human   219 VLNLAVWVFIMIAGLFFINGKYW-----------AEGQFLPHGWSGVLQGAATCFYAFIGFDIIA 272

  Fly   254 TTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKWI 318
            ||||||.||..:||.:|..||:|...:|..||.:||:|:|||..|.::|....|.:..:|..|::
Human   273 TTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFV 337

  Fly   319 VTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLF 383
            |.||:|..|..||||::||:||::|||..||:||:.|:.|:|||:||::|.||||..|:::|:|.
Human   338 VAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLV 402

  Fly   384 NLDQLVDMMSIGTLLAYTIVAICVLVLRYQ------------DEEMTK----------------- 419
            :|..|::|||||||||||:|::|||:||||            .||.||
Human   403 SLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPV 467

  Fly   420 --------------------------------------------------------------LVS 422
                                                                          |:.
Human   468 SEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIK 532

  Fly   423 VK---APNVF----RQFFNGNSFREPNSMTSSITKVGIVVFAIFCLVWCSLQKVFDLD--STGGI 478
            :|   .|:.:    |....|...| |.:.|.....:.:::..|...::||. .:|..|  |....
Human   533 LKKLIGPHYYTMRIRLGLPGKMDR-PTAATGHTVTICVLLLFILMFIFCSF-IIFGSDYISEQSW 595

  Fly   479 VALSLVGAVLILICV---VIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLI 540
            .|:.||..:::||..   ||..||.:..:|.:..|.:||||..::..|:|||.:|...|||||.:
Human   596 WAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAV 660

  Fly   541 WIVIGYVIYFCYGMRNSTQISRSRSHAEVAASALQNQGQHVNPGFEPDYKVENG 594
            |..:|.:|||.||:.|||....:|..|       .:|..:.....:..:.||.|
Human   661 WCFVGLLIYFGYGIWNSTLEISAREEA-------LHQSTYQRYDVDDPFSVEEG 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	252/663 (38%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	22/49 (45%)
SLC7A14	NP_066000.2	2A0303	48..677	CDD:273330	248/642 (39%)
		AA_permease_C	627..677	CDD:290617	22/49 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D439017at2759
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830