DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and slc7a1a

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_021327949.1	Gene:	slc7a1a / 559627	ZFINID:	ZDB-GENE-091116-69	Length:	651	Species:	Danio rerio

Alignment Length:	609	Identity:	297/609 - (48%)
Similarity:	392/609 - (64%)	Gaps:	59/609 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIAAI 70
            |.|.|.|..:.|..||:|:|.||.|||.|||||||||.|||||||.||...||||:.:||||||:
Zfish    11 KQLLRVKVVNCNSEESRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVLSFLIAAL 75

  Fly    71 ASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLI 135
            ||..||:|||||.|||||.||||:|||||:||..||..||||||.|||||:||||..|..||.||
Zfish    76 ASVLAGLCYAEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYVIGTSSVARAWSATFDELI 140

  Fly   136 NNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIVL 199
            ..::.....:.|.::. ..|.:|||..|..::|.|..:||||.|||:.:|.:||.:|::.:..::
Zfish   141 GKHIEHFCRQYMSMNAPGVLAEYPDMFSVFIILTLTGLLAFGVKESAMVNKVFTCINILVLLFMV 205

  Fly   200 VAGAMNANVDNWRIPKKDV----------------PEGFGTGGFMPFGIAGVMAGAAKCFYGFVG 248
            |:|.:...:.||.:...::                .|..|.|||||||..||::|||.|||.|||
Zfish   206 VSGLVKGTLKNWHLDPDEILNATNSTLNATQPLPSEEMLGQGGFMPFGFTGVLSGAATCFYAFVG 270

  Fly   249 FDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWY 313
            ||||||||||..||:|.||:.||.||:|.|::|||||..||||:|||..||::|.|.||..|.|.
Zfish   271 FDCIATTGEEVKNPQRAIPIGIVSSLLICFVAYFGVSAALTMMMPYYMLDKNSPLPVAFKYVGWE 335

  Fly   314 TIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASI 378
            ...:.|.:|::.||.|||||||||:||:|:||..||:|||.::.::..||||:.|||:||..|:|
Zfish   336 GATYAVAVGSLCALSTSLLGAMFPMPRVLWAMADDGLLFKFMAGISERTKTPIKATIMSGFLAAI 400

  Fly   379 MAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQ---------------DEEMTKLVSVKA--- 425
            ||.||:|..|||:||||||||||:||.||||||||               |.||::.:|..:
Zfish   401 MAFLFDLKDLVDLMSIGTLLAYTLVAACVLVLRYQPEQFSQTYHIANTHEDMEMSETISTPSMGI 465

  Fly   426 -PNVFRQFFNGNSFR--------EPNSMTSSITKVGIVVFAIFCLVWCSLQKVFDLDSTGGIVAL 481
             |.|..:|    ||:        ||::::.....:...:..:..|.: ||..|     .|||.:.
Zfish   466 LPGVEERF----SFKNLLFPDIIEPSNLSGFTVNICTSLLGLLILSF-SLLAV-----RGGIASW 520

  Fly   482 SLVG-AVLILICV----VIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIW 541
            :::. |||..:||    :|..||.|..:|:||||.:||:|.:|:|.|:|||.|||..|||||.||
Zfish   521 NIITLAVLFGLCVIVTFIIWRQPESKTKLSFKVPCLPFIPVVSMFVNVYLMMQLDRGTWIRFAIW 585

  Fly   542 IVIGYVIYFCYGMRNSTQISRSRS 565
            :.||.||||.||:.:||:.:.:.|
Zfish   586 MSIGLVIYFGYGIWHSTEAALAHS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	293/597 (49%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	31/49 (63%)
slc7a1a	XP_021327949.1	2A0303	4..603	CDD:273330	295/601 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593067
Domainoid	1	1.000	463	1.000	Domainoid score	I454
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1071
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm6524
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940