DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Slc7a4

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001100548.1	Gene:	Slc7a4 / 303787	RGDID:	1305905	Length:	635	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	239/620 - (38%)
Similarity:	362/620 - (58%)	Gaps:	59/620 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIAAIAS 72
            |.|.|..:.:..|:.|.|.|:..|||.||||..:|.|:|||.|.||.::|||||.:|||:||:||
  Rat    18 LNRLKPLEESSTETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGTVAKDMAGPAVLLSFLVAAVAS 82

  Fly    73 AFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLINN 137
            ..|.:|||||.||||:.||||:::||::||..||.||||::|||:||.|:|||..|||.|::.|:
  Rat    83 LLAALCYAEFGARVPRTGSAYLFTYVSMGEIWAFLIGWNVLLEYLIGGAAVARAWSGYLDAIFNH 147

  Fly   138 NMSKALNESMHI-DVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIVLVA 201
            ::.......|.: .:.||..|||||:.|::|:.:|.::.||:.||:||:.|:.::|:.|..::|.
  Rat   148 SIRNFTESHMGVWQMPFLAHYPDFLAAGILLVASAFVSCGARVSSWLNHTFSAISLIVILFIIVL 212

  Fly   202 GAMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGEEAINPKRNI 266
            |.:.|...||...:         |||.|||.:|::||.|.|||.|||||.||.:.|||.||:..:
  Rat   213 GFILARPHNWSAEE---------GGFAPFGFSGILAGTATCFYAFVGFDVIAASSEEAKNPRWAV 268

  Fly   267 PLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKWIVTIGAVFALCTSL 331
            |::|.:||.:...:|..||||||:|:|::..|.|:....||....:....:||.:|::.|:.|.|
  Rat   269 PMAIAISLGLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYGWAGFIVAVGSICAMNTVL 333

  Fly   332 LGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLDQLVDMMSIGT 396
            |..:|.||||:|||..||:.|:..:.|:..|:.|::..:|.|:..:::|:|.:|:.||..:||||
  Rat   334 LSNLFSLPRIVYAMAADGLFFQVFARVHPRTQVPVVGILVFGVLMALLALLMDLEALVQFLSIGT 398

  Fly   397 LLAYTIVAICVLVLRYQD----------------------EEMTKLV-----SVKAPNVFRQ--- 431
            |||||.||..::|||:|.                      .:..:||     |:..|...|.
  Rat   399 LLAYTFVATSIIVLRFQKASPPSSPCPASPGPTVKKYDSFSDHIQLVDAVQASMSEPGQLRPALK 463

  Fly   432 ----FFNGNSFREPNSMTSSITKVGIVVFAIFCLVWCSL---QKVFDLDSTGGIVALSLVGAVLI 489
                |.:|.|   |.  |:....:||::.:...|. |.|   .....|...|.::.|.:.|||.:
  Rat   464 PFLGFLDGLS---PG--TAVTWALGILIASAISLA-CVLVFGNSALHLPRWGYVLLLVVSGAVFL 522

  Fly   490 LICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFCYGM 554
            ...:|:|.......:.||::||||..|.||:..||.||.:|...||:||:.|:::|.|:||.||:
  Rat   523 SSLLVLGAHQQQKKQDTFQIPLVPLTPALSILLNLCLMLKLSYLTWLRFIFWLLVGLVVYFGYGI 587

  Fly   555 RNSTQISR-----SRSHAEVAAS-ALQNQGQHVNP 583
            .:|.:..|     :.:|..|..| :|:...|.|.|
  Rat   588 WHSKENQREPLELTTAHYVVFPSGSLEETVQAVQP 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	230/586 (39%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	24/49 (49%)
Slc7a4	NP_001100548.1	2A0303	14..592	CDD:273330	231/588 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650