DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Slc7a12

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001011948.1	Gene:	Slc7a12 / 294881	RGDID:	1309208	Length:	472	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	101/476 - (21%)
Similarity:	189/476 - (39%)	Gaps:	81/476 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QLARVLNLFDLTALGVGSTLGLGVYVLAGQV----AFNIAGPAVTISFLIAAIASAFAGICYAEF 82
            ||.|.|..|.:......:|:|.|::|....|    :.||  |.....:....:.|....:|.||.
  Rat     2 QLLRGLGFFHVNMFLFSATIGTGIFVSPKGVLKYCSLNI--PIFLSIWAGCGLLSMMNAVCLAEI 64

  Fly    83 AARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTAS----VARGLSGYFDS------LINN 137
            ||..|.:|::|.:....:|..|||...|..|....:|.::    :|..|...|.|      |...
  Rat    65 AATYPVSGASYYFLKRALGSSVAFLSIWIKIFACTLGISAQCLLIASSLIQCFYSECQAPELPKK 129

  Fly   138 NMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIVLVAG 202
            .::.|:                ..|||:      :.|.|.|..::.|.|.:.:.|..:.::.:.|
  Rat   130 CLALAI----------------LWSFGI------LSARGIKPVAWFNTISSLMKLSVLCLISLTG 172

  Fly   203 AM------NANVDNW-RIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGEEAI 260
            .:      ..||..: :..:.::|           .::.:.....:.:|.::|...:.....|..
  Rat   173 IVLLVIGKKENVSRFEKALEAELP-----------NVSQIAEAILQVYYAYLGSSFLIVIAGEIK 226

  Fly   261 NPKRNIPLSIVVSLIIIFLSYFGVSTVLTMML---PYYKQDKDAPFPHAFDSVEWY-----TIKW 317
            .|...||.||:..|.::.:.|...:.....:|   .....|..|        |.|.     :::|
  Rat   227 RPAETIPKSIIYGLSVVTVLYLLTNVSFLAVLTSEEIISSDSVA--------VTWMNRVFPSMQW 283

  Fly   318 IVTIGAVFALCTSLLGAMFPLPRILYAMGKDG---ILFKRLSTVNSYTKTPLLATIVSGIFASIM 379
            |:::.....|..|:...:....||.||..::|   .::..|:.::|    |::|.:.:.|.:|:.
  Rat   284 IISLLISAFLFGSVSCGIVSASRIFYATSQEGQFPFIYSMLNDLHS----PVVADLQAVILSSVG 344

  Fly   380 AMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNVFRQFFNG-NSFREPNS 443
            .:..|:..|:..:.:||.....:..|.:|.||||:.::.:...|:.|.||....:. .....|..
  Rat   345 IISSNMIYLIKYVGLGTWCLNLLNMIGLLKLRYQNPDLPRPYKVRLPFVFGSIASSLFLILTPVI 409

  Fly   444 MTSSITKVGIVVFAIFCLVWC 464
            .:.|...|..||| :||.:.|
  Rat   410 QSPSTEHVYQVVF-LFCGLLC 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	101/476 (21%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
Slc7a12	NP_001011948.1	2A0308	21..423	CDD:273332	92/449 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930