DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and LOC292543

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006228084.2	Gene:	LOC292543 / 292543	RGDID:	1565097	Length:	681	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	279/627 - (44%)
Similarity:	392/627 - (62%)	Gaps:	53/627 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LW--------KALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPA 60
            ||        |.:.||......:.||.|:|.|...||.:||||||||.|||||||:||...|||:
  Rat    51 LWQNLHQFGQKLVRRRPLAASEQSESSLSRCLTTLDLVSLGVGSTLGAGVYVLAGEVAREKAGPS 115

  Fly    61 VTISFLIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVAR 125
            :.|.|||||::|..:|:|||||.||||.:||||:|||||:|:.:||..||||||.||||.|||||
  Rat   116 IIICFLIAALSSVMSGLCYAEFGARVPCSGSAYLYSYVTVGQLLAFITGWNLILNYVIGAASVAR 180

  Fly   126 GLSGYFDSLINNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTT 189
            ..|..||.||.|::|:||..:..|.| .||..||||.:.|:|::|..|||.||:||:.:..:||.
  Rat   181 AWSAAFDGLIGNHISQALQTTFPIQVPSFLAKYPDFFALGLVIVLTGILALGARESAMVTRVFTG 245

  Fly   190 VNLVTIAIVLVAGAMNANVDNWRIPKKDVPEG------------FGTGGFMPFGIAGVMAGAAKC 242
            |||:.:..|.::|.:|..:.||::.:.|....            .|:|||||||:.|::.|.|.|
  Rat   246 VNLLVLCFVSLSGFINGKLHNWQLTEDDYKLALSETNSTDSLGPLGSGGFMPFGLTGILRGTATC 310

  Fly   243 FYGFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAF 307
            |:.|:||||||:|||||..|:|:|||.||:||.|.||.|||||:.||:|:|||:.:.::|.|.||
  Rat   311 FFAFIGFDCIASTGEEARCPQRSIPLGIVISLFICFLMYFGVSSALTLMMPYYQININSPLPQAF 375

  Fly   308 DSVEWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVS 372
            ..|.|...::.|.:|.:.||.:||:|::||:||::|:|.:||:||::|:.|:..|.||:|||::.
  Rat   376 IHVGWGPARYAVAVGTLCALSSSLIGSIFPVPRVVYSMAEDGLLFRKLAQVHPRTHTPVLATVLC 440

  Fly   373 GIFASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQ-DEEMTKLVSVKAPNVFRQFFNG- 435
            |:.|:.||.|..|..|||:.||||||||::||..||||||| |:.::.....|:.::..:...|
  Rat   441 GVIAAFMAFLVELSDLVDLSSIGTLLAYSLVAFSVLVLRYQPDQNLSSCKKEKSDSMAVELEPGL 505

  Fly   436 --NSFREPNSM---------------TSSITKVGIVVF------AIFCLVWCSLQKVFDLDSTGG 477
              :|..||.|.               |:...:.|.:|:      |:..:..|.:...:......|
  Rat   506 ELSSCMEPMSPEGTPGIARGLCMPMDTTPTLRSGRIVYGCASLLALLLVFLCLILVQWSTQLFSG 570

  Fly   478 IVALSLVGAVLILICV----VIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRF 538
            ...|..|...|.|:.|    ||..||.|||.|.||||.:|.:|.||:|.|:|||.|:...|||||
  Rat   571 NPVLIAVAVSLFLLTVGVVTVIWRQPQSTIPLHFKVPALPVLPVLSIFVNIYLMMQMTTGTWIRF 635

  Fly   539 LIWIVIGYVIYFCYGMRNSTQISRSRSHAEVAASALQNQGQH 580
            .||:|||:.|||.||:::|.:   .::..:..||:.|...:|
  Rat   636 GIWMVIGFAIYFGYGIQHSLE---EKNDQQPTASSSQTPQEH 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	271/590 (46%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	29/49 (59%)
LOC292543	XP_006228084.2	2A0303	53..656	CDD:273330	273/602 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351251
Domainoid	1	1.000	457	1.000	Domainoid score	I470
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1161
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8968
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910