DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Slc7a11

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_036120.1	Gene:	Slc7a11 / 26570	MGIID:	1347355	Length:	502	Species:	Mus musculus

Alignment Length:	518	Identity:	113/518 - (21%)
Similarity:	191/518 - (36%)	Gaps:	124/518 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIA-AIASAFAGICYAEFAARV 86
            |.:.:.|....::.:|:.:|.|:::....:..|.....:::.|..| .:.|.|..:.|||....:
Mouse    40 LKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGTSI 104

  Fly    87 PKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLINNNMSKALNESMHIDV 151
            .|:|..|.|.....|..:||...|..:|....|..:|           |:....:.:.|...|..
Mouse   105 KKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAV-----------ISLAFGRYILEPFFIQC 158

  Fly   152 DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNN----------IFTT-VNLVTIAIVLVAGAMN 205
            :.    |:       |.:..:.|.|......||:          ||.| ..|..|.|::|.|.:.
Mouse   159 EI----PE-------LAIKLVTAVGITVVMVLNSTSVSWSARIQIFLTFCKLTAILIIIVPGVIQ 212

  Fly   206 ANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGEEAINPKRNIPLSI 270
            . :.......||...|..|      .:.|:........|.:.|:..:....||..||::.|||:|
Mouse   213 L-IKGQTHHFKDAFSGRDT------SLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAI 270

  Fly   271 VVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTI-------------------- 315
            .:|:.||.:.|     |||                   :|.::|.
Mouse   271 CISMAIITVGY-----VLT-------------------NVAYFTTISAEELLQSSAVAVTFSERL 311

  Fly   316 --KWIVTIGAVFALCT--SLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFA 376
              |:.:.:....||..  |:.|.:|.:.|:.|...::|.|.:.||.::.:..|||.|.||  :..
Mouse   312 LGKFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIV--LHP 374

  Fly   377 SIMAMLFNLD--QLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNVFRQFFNGNSFR 439
            ..|.|||:.|  .|::.:|....|...:....::.|||           |.|::.|.|
Mouse   375 LTMVMLFSGDLYSLLNFLSFARWLFMGLAVAGLIYLRY-----------KRPDMHRPF------- 421

  Fly   440 EPNSMTSSITKVGIVVFAIF---CLVWCSLQKVFDLDSTGGIVALSLVGAVLILICVVIGMQP 499
                      ||.:.:.|:|   ||....|....|..|||....::|.|.....:.:|...:|
Mouse   422 ----------KVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLITLTGVPAYYLFIVWDKKP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	113/518 (22%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
Slc7a11	NP_036120.1	2A0308	1..498	CDD:273332	113/518 (22%)
Slc7a11	NP_036120.1	SLC5-6-like_sbd	42..>291	CDD:294310	63/301 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940