DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and Slc7a1

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_037243.2	Gene:	Slc7a1 / 25648	RGDID:	3716	Length:	624	Species:	Rattus norvegicus

Alignment Length:	631	Identity:	281/631 - (44%)
Similarity:	387/631 - (61%)	Gaps:	73/631 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNLWKALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISF 65
            :.:|.:...|||..|.:..||:|:|.||.:||.|||||||||.|||||||.||...||||:.|||
  Rat     6 LLSLGQQTLRRKVVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISF 70

  Fly    66 LIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGY 130
            ||||:||..||:||.||.|||||.||||:|||||:||..||..||||||.|:|||:||||..|..
  Rat    71 LIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSAT 135

  Fly   131 FDSLINNNMSKALNESMHIDV-DFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVT 194
            ||.||...:.:...:.|.::. ..|...||..:..::::|..:|..|.|||:.:|.|||.:|::.
  Rat   136 FDELIGKPIGEFSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLV 200

  Fly   195 IAIVLVAGAMNANVDNWRIPK---------KDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFD 250
            :..::|:|.:..:::||::.:         .|....:|.|||||||.:||::|||.|||.|||||
  Rat   201 LCFIMVSGFVKGSIENWQLTENKSSPLCGNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFD 265

  Fly   251 CIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTI 315
            ||||||||..||::.||:.||.||:|.|::|||||..||:|:||:..|.|:|.|.||....|...
  Rat   266 CIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDTDSPLPGAFKYRGWEEA 330

  Fly   316 KWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMA 380
            |:.|.:|::.||.|||||:|||:||::|||.:||:|||.|:.:|..||||::||:.||..|::||
  Rat   331 KYAVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINDRTKTPIIATVTSGAIAAVMA 395

  Fly   381 MLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNVFRQF------------- 432
            .||.|..|||:|||||||||::||.||||||||.|:         ||:..|.
  Rat   396 FLFELKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQ---------PNLVYQMARTTDELDQVDQN 451

  Fly   433 ------------------FNGNSFREPNSMTSS-----ITKVGIVVFAIFCLVWCSLQKVFDLDS 474
                              |:..:...|.:|..|     |..:...:.|:..:..|.:..:
  Rat   452 EMVSASESQTGFLPAAEKFSLKTILSPKNMEPSKFSGLIVNISAGLLAVLIITVCIVAVL----- 511

  Fly   475 TGGIVALS---------LVGAVLI--LICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMF 528
              |..||:         :.|:||:  |:..:|..||.|..:|:||||.||.:|.||:|.|:|||.
  Rat   512 --GREALAEGTLWAVFVMTGSVLLCMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNIYLMM 574

  Fly   529 QLDLNTWIRFLIWIVIGYVIYFCYGMRNSTQISRSRSHAEVAASAL 574
            |||..||:||.:|::||:.|||.||..:|.:.|.:...|:...|.|
  Rat   575 QLDQGTWVRFAVWMLIGFAIYFGYGAWHSEEASLAAGQAKTPDSNL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	275/605 (45%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	29/49 (59%)
Slc7a1	NP_037243.2	2A0303	4..605	CDD:273330	277/614 (45%)
Slc7a1	NP_037243.2	AA_permease_C	553..603	CDD:290617	29/49 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351270
Domainoid	1	1.000	457	1.000	Domainoid score	I470
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1161
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8968
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810