DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and SPCC74.04

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_588377.1	Gene:	SPCC74.04 / 2539069	PomBaseID:	SPCC74.04	Length:	557	Species:	Schizosaccharomyces pombe

Alignment Length:	632	Identity:	128/632 - (20%)
Similarity:	229/632 - (36%)	Gaps:	179/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NLFDLTALGVGSTL--GLGVYVLAGQVAFNIAG------------------PAVTISFLIAAIAS 72
            |..||.|||.....  ||.::.:. .|:|::.|                  |.:...:|||.:..
pombe    43 NAEDLAALGYKQEFQRGLSLFSVF-SVSFSLLGLLPSVATTLPYSIGYTGTPGLLWGWLIAMVFI 106

  Fly    73 AFAGICYAEFAARVPKAGSAYVYSYVTI----GEFVAFTIGWNLILEYVIGTASVARGLSGYFDS 133
            ....:..||..:.:|.:|..|..:.|..    |...|:..||:..:..::|..|:....:.....
pombe   107 ICIALSMAELCSAMPTSGGLYYAAAVLAPEGWGPLAAWFTGWSNYIAQLVGGPSINYSTAAMLLG 171

  Fly   134 LINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILA-----FGAKESS---FLNNIFTTV 190
            .:|..     |.:..:.     :|..||....:..:..|||     :.||.:|   :||.:|..:
pombe   172 AVNIG-----NPNYEVQ-----NYQLFLVSIAIQFIHFILASMPTKYIAKLNSVGTYLNTLFLFI 226

  Fly   191 NLVTIAIVLVAGAMN----------ANVDNWRIPKKDVPEGFGTGGFMPF-GIAGVMAGAAKCFY 244
            :::   ::|...:.|          ::::|:    .|.|:||..  .|.| |:...|:
pombe   227 SMI---VILAMSSKNHGFNETSKVWSHIENY----TDWPDGFAI--LMSFCGVIWTMS------- 275

  Fly   245 GFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDS 309
               |:|......||..|...|.|..|:::..|..:    :..|:.:::.|...|:.|....: ||
pombe   276 ---GYDAPFHMSEETANASVNAPRGIILTAAIGGI----MGWVMQIVIAYTVVDQTAVVTGS-DS 332

  Fly   310 VEWYTI-------KWIVTIGAVFALCTSLLGA--MFPLPRILYAMGKDGIL--FKRLSTVNSYTK 363
            : |.|.       :..:.|.::..:.:.|:|.  :....||.|:..:||:|  .:.::|||..||
pombe   333 M-WATYLSQCLPKRAALGILSLTIVSSFLMGQSNLIASSRIAYSYARDGVLPYSEWVATVNPITK 396

  Fly   364 TPLLATIVSGIFASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNV 428
            ||:.|..|:.:...::..|    .....::||.:.:.|.:|           ..|..|:..|..|
pombe   397 TPIRAVFVNFVIGVLILFL----AFAGAITIGAVFSVTAIA-----------AFTAFVAPVAMRV 446

  Fly   429 FRQFFNGNSFRE-PNSMTSSITKVGIVVFAIFCLVWCSLQKVFDLDSTGGIVALSLVGAVLILIC 492
            |  |.....||. |.::......:|      ||                   ::|.|..::.::|
pombe   447 F--FVKDADFRTGPFNLGKFSKPIG------FC-------------------SVSFVALMIPILC 484

  Fly   493 VVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFCYGMRNS 557
            ......| :..|:.:.. ||...|.|:|                  |||..|....:|
pombe   485 FPSVKNP-TPAEMNWTC-LVFGAPMLAV------------------LIWYAISGRKWF------- 522

  Fly   558 TQISRSRSHAEVAASALQNQGQHVNPGFEPDYKVENGGRPYEFSEKL 604
                               :|..:|...|.|.....|...|..||:|
pombe   523 -------------------KGPRINLASEGDNSTLEGVELYTGSEEL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	119/583 (20%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	10/49 (20%)
SPCC74.04	NP_588377.1	2A0304	47..525	CDD:273331	117/601 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030