DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Y53F4B.12

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001293550.1	Gene:	Y53F4B.12 / 190214	WormBaseID:	WBGene00013159	Length:	762	Species:	Caenorhabditis elegans

Alignment Length:	777	Identity:	134/777 - (17%)
Similarity:	267/777 - (34%)	Gaps:	245/777 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWKALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIA 68
            |.|.|..|:.::.....|:.||.|.:..:.||....::.:.::::.......:|||:..::.:.|
Worm     5 LQKMLRTRRVDEQFLRHSEWARRLGVPLMVALAGIKSISMMLFIILPFSLTQVAGPSTVLAPIFA 69

  Fly    69 AIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDS 133
            .:...|:....:|.:..:||....|.::|..|||..||.|.|..:::||.......:..:.:|:.
Worm    70 FLIIFFSAAHLSELSCTMPKNCVQYHFAYAVIGELPAFVIAWISLVDYVAQAGLFCKAWADHFNL 134

  Fly   134 LINNNMSKALN-ESMHIDVDFLGDYPDFLS-----FGMVLLLAAILAFGAKESSFLNNIFTTVNL 192
            |.....:|:|. :....|...|....|.|:     ..:.|||.::...|.          ..|:|
Worm   135 LFRGLPAKSLTFDVFSTDSMLLSPQVDLLTVLSAIITLCLLLCSLRVVGT----------ICVSL 189

  Fly   193 VTIAIVLVAGA-----MNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVM---AGAAKCFYGFVGF 249
            :.:.:::.|..     .:::.:||.           ...|..||..||:   .....|:.|....
Worm   190 LAVTLLIAASCTMVAFFHSDPENWI-----------KAEFFHFGYQGVLYAICALCACYTGIEST 243

  Fly   250 DCIATTGEEAINPKRNIP-----LSIVVSLIIIFLSY-FGVSTVLT------------------- 289
            .|:.   ||..||::.|.     |.:|::.|...||. |.:||.:|
Worm   244 SCLL---EETKNPRKRISGVLSFLVLVLTTIFFVLSITFSLSTNVTALSEGIMIPEVFSVINIPA 305

  Fly   290 -------------MMLPYYKQDKDAPFPHAFDSVEWY-----TIKWIVTIGAVFALCTSLLGAMF 336
                         |:.|.......:..|.||.|  :|     .:::::::.:|.||...:|.:..
Worm   306 AKSSSKHWVRRFPMISPSESATSSSISPSAFRS--YYEQGFIRMRYMLSVCSVCALSGGVLASFL 368

  Fly   337 PLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLDQLVDMMSIGTLLAYT 401
            |..|::.|:..|.::.....|   .||:|..|.::..:..::.:|:    |...:::....:|..
Worm   369 PATRVIAALCHDRLIPYAKDT---STKSPYFAVLLCTVLVALCSMI----QKTMLLNFVIFMAPV 426

  Fly   402 IVAICVLVL---RYQDEEM---------------------------------------------- 417
            .:.|.:|::   .|..|::
Worm   427 KLVITILLVYLQHYYPEQIGIPEETSNYKSIGKKRTRVHIDDGVSIDDSVSLIPSRHLEDHDDQS 491

  Fly   418 -----------------TKLVSVKA-----------------------------PNV-------- 428
                             ||:.|.:.                             ||:
Worm   492 EVSHSTFDTTAFLYMKATKMESERLQKRLEKEQLENEELQPVLAKSVSQYHTMDPNLKKAKKIKK 556

  Fly   429 ----------------------------------FRQFFNGNSFREPNSMTSSIT--KVGIVVFA 457
                                              |...|:.::.|.|:...|..|  :...::|
Worm   557 HAHNCVAEQCGAENDDDFNSQEVHLFANEEPELPFFSTFSSSAPRPPSPDVSFATFHRSRRLLF- 620

  Fly   458 IFCLVWCSLQKVFDLDSTGGIVALSL-VGAVLILICVVIGMQPVSTIELTF-KVPLVPFVPCLSV 520
            :||:|.|:........:...:....| :|.||:::...:.:..:.|.:..: |...|...|..|:
Worm   621 LFCVVTCAFSAFLRNYAVPTVTCWMLSIGFVLVIVVFTVNINRLQTNDYLYKKESKVTLFPTTSL 685

  Fly   521 FANLYLMF-----QLDLNTWIRFLIWIVIGYVIYFCYGMRNSTQISRSRSHAEVAASALQNQ 577
            | .|:::.     .:...|....::..:||.:.||.||.|:|       .|.:.|...::|:
Worm   686 F-TLFMLLGSFAGSVPTKTLAHLVVIPLIGILAYFLYGYRHS-------KHRKTACLVIENR 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	128/751 (17%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	14/55 (25%)
Y53F4B.12	NP_001293550.1	2A0303	3..>407	CDD:273330	88/430 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.820