DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and aat-7

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_493960.3	Gene:	aat-7 / 186240	WormBaseID:	WBGene00000008	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	105/530 - (19%)
Similarity:	209/530 - (39%)	Gaps:	123/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VNEGESQLARVLNLFDLTALG--VGSTLGLGVYVLAGQVAFNIAGPAVTIS---FLIAAIASAFA 75
            :.|..|::.:...:..:||:.  ||..:|.|:::....: .|.|| :|.:|   :.:.|..|.|.
Worm     1 MTESSSEIPQKHTIGLITAISYTVGDIVGSGIFISPTSI-LNHAG-SVGLSLCLWALCACISLFG 63

  Fly    76 GICYAEFAARVPKAGSAYVY--------------------SYVTIGEFVAFTIGWNLILEYVIGT 120
            .:.|.|....:.|:|..:.|                    ||..:....|.:.|     ||::
Worm    64 ALSYVELGTSIRKSGCDFAYLSHFGWRPLASSFMWVSTCLSYPAVLAIQAISFG-----EYIV-- 121

  Fly   121 ASVARGLSGYFDSLINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKE-SSFLN 184
                .||    ||.|.            ||.::.......:.|.|:..|..:..|..|: :....
Worm   122 ----TGL----DSWIT------------IDENWRFMTYRLVGFSMLWPLMLLNFFSLKKVAGAFQ 166

  Fly   185 NIFTTVNLVTIAIVLVAGAMNANVDNWRIPKKDVPEGFG---TGGFMPFG--IAGVMAGAAKCFY 244
            .:.|.:.|:..:|:::.|.       :.|..|...:.|.   ||.....|  :.||.:|    .:
Worm   167 IVATAIKLIVASIIIITGL-------YHIIFKQQTQNFKNSFTGSDWNPGNLVLGVYSG----LF 220

  Fly   245 GFVGFDCIATTGEEAINPKRNIPLSIVVSL-------IIIFLSYFGVSTVLTMMLPYYKQDKDAP 302
            .:.|:|.:....||..||:|.:|::.:..:       |::.:|||.|.:|        :..|::|
Worm   221 AYNGWDVLNFGAEEIENPRRTLPIAAISGIAISATVFILMNVSYFSVLSV--------EDFKNSP 277

  Fly   303 -----FPHAFDSVEWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYT 362
                 |.........|.|.:::::..:.::.|::    |...|.:|:..:..::...|..::..|
Worm   278 AVAVTFAERTLGDFHYAIPFLISLLLIGSMNTTI----FACSRYMYSGAQQSVMPTPLRGIHHRT 338

  Fly   363 KTPLLATIVSGIFASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPN 427
            ::|.||.....:.|..::.:.|||||:..||.......|...:..:..:.:....|:
Worm   339 RSPRLAVFAEILIAICLSFIGNLDQLISYMSFALWSQRTCTQVGFIYFKLRGTLKTQ-------- 395

  Fly   428 VFRQFFNGNSFREPNSMTSSITKVGIVVFAIFC--LVWCSLQKVFDLDSTGGIVALSLVGAVLIL 490
                    :||:.|..:.        |||...|  |:...:.:.:.:...|  |::::.||::.|
Worm   396 --------DSFQVPIFVP--------VVFLGICIALLVIPITQNYHVAIYG--VSMTIGGAIIYL 442

  Fly   491 ICVVIGMQPV 500
            |.:.....|:
Worm   443 IFIFPNTLPI 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	105/530 (20%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
aat-7	NP_493960.3	2A0308	11..472	CDD:273332	103/520 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920