DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and aat-1

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_501707.1	Gene:	aat-1 / 177793	WormBaseID:	WBGene00000002	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	116/533 - (21%)
Similarity:	209/533 - (39%)	Gaps:	115/533 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNLWKALTRRKTEDVNEGESQ-----LARVLNLFDLTALGVGSTLGLGVYV-------LAGQVA 53
            ||...:.|..|:.::..:.|::     |.:.|.||:..::.||..:|.|::|       .||.|.
Worm     1 MTAEKEPLKSREGDEAPQNETEGKGKGLEKSLTLFNGVSMIVGCIIGSGIFVSPTGVQEQAGSVG 65

  Fly    54 FNIAGPAVTISFLIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVI 118
            .::      |.:||:.|.:|....||||....:.|:|..|.|.....|.||||...|  |...|:
Worm    66 LSL------IVWLISGIFTAIGAYCYAELGTLIKKSGGDYAYIMEAFGPFVAFIRLW--IEAIVV 122

  Fly   119 GTASVA--------RGLSGYFDSLINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAF 175
            ...:|.        .||..:|......::                 ..:.|:..:::|:.||...
Worm   123 RPCTVTIVALTFAIYGLRPFFPDCAPPDV-----------------VAELLAILLIVLMTAINCI 170

  Fly   176 GAKESSFLNNIFTTVNLVTIAIVLVAGAMNANVDNWRIPKKDVPEGFGTGGFMPFG-------IA 233
            ..:.::.:.:.||...:|.:.::::.|.                      |.:.||       ..
Worm   171 SVRLATIVQDWFTIAKVVALCLIILTGL----------------------GLLFFGESQYKDSFE 213

  Fly   234 GVMAGAAKCF-----------YGFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTV 287
            .:....::.|           :.:.|::.:....||..|||||:||:|.:|:....:.|     |
Worm   214 NIFENTSQDFTKVSLAFYSGLFAYSGWNFLNFIVEELQNPKRNLPLAIAISITSCTVIY-----V 273

  Fly   288 LTMMLPYYKQDKDAPFPHAFDSVEWYTIKWIVTIGAVFALCT------SLLGAMFPLPRILYAMG 346
            ||.:..|.....|........:| .:..|.......:..||.      |..|.:|...|:.|:..
Worm   274 LTNVALYTAISPDEMLESPAVAV-LFANKLYGKFAFIMPLCVACSTIGSANGVIFTSARLFYSGA 337

  Fly   347 KDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLD--QLVDMMSIGTLLAYTIVAICVLV 409
            ::|.:...|:.:|..||||:.|.|::|.. ||..:|.:.|  ||::.:.|...||.......:..
Worm   338 REGQMPAVLTMINKKTKTPIPAVILTGAL-SIAYLLASKDVYQLINYIQISYWLAIGTAIAALFW 401

  Fly   410 LRYQDEEMTKLVSVKAPNVFRQFFNGNSFR---EPNSMTSSITKVGIV-------VFAIFCLVWC 464
            ||....:.::  .:|.|.::...|......   .|.......|.:|::       |:.|| :.|.
Worm   402 LRRTMPDASR--PIKVPLIWPAIFLAGCIALVLIPMVAAPRDTGIGLLIMLSAVPVYGIF-IGWK 463

  Fly   465 SLQKVFD--LDST 475
            :..|.|:  :||:
Worm   464 NKPKWFNEFIDSS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	114/526 (22%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
aat-1	NP_501707.1	2A0308	2..491	CDD:273332	115/532 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920