DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and Slc7a12

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	497	Identity:	106/497 - (21%)
Similarity:	195/497 - (39%)	Gaps:	125/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIAA---IASAFAGICYAEFA 83
            ||.|.|.:|.::.:...:|||.|::| ..:.....:...:.:|..|.|   :.|..:.:|.||.|
Mouse     2 QLLRALGVFHVSMILFSATLGTGIFV-TPKAVLKYSSLNIPVSLSIWAGCGLLSIMSALCNAEIA 65

  Fly    84 ARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTAS----VARGLSGYFDS------LINNN 138
            ...|.:|::|.:...|:|..|||...|..:..:.:|..:    :|..:...|.|      |....
Mouse    66 TTYPLSGASYYFLKRTLGSSVAFLSLWIKLFAHFLGIGAQCLLIATSVIQCFYSGCPAPELPTKC 130

  Fly   139 MSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVN-----LVTIAIV 198
            ::.|:                ..|||:|      .|.|.|..::.|.:.:.:.     |:::.::
Mouse   131 LALAI----------------LWSFGIV------SARGIKTVAWFNTVSSFIKLSVLCLISLTVL 173

  Fly   199 LVAG----------AMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGA-AKCFYGFVGFDCI 252
            ||.|          |::|.:.|                      |..:|.| .:..|.::|...:
Mouse   174 LVNGKKENVSRFENALDAELPN----------------------ASQIADAILQVSYSYLGSSVL 216

  Fly   253 ATTGEEAINPKRNIPLSIV--VSLIIIF-----LSYFGVSTVLTMMLPYYKQDKDAPFPHAFDS- 309
            .....|...|...||.:::  :|::.:.     :||..|.|...::..              ||
Mouse   217 IVIAGEIKRPTETIPKTLIYGISIVTVLYLLTNISYLAVLTSQEIIFS--------------DSV 267

  Fly   310 -VEWY-----TIKWIVTIGAVFALCTSLLGA----MFPLPRILYAMGKDGILFKRLSTVNSYTKT 364
             |.|.     :|:||    :.|.:...|||:    :....|:.|:..::|......|.:|.: .:
Mouse   268 GVTWMNRVFPSIQWI----SSFLISAFLLGSVSCGIVSASRVFYSASQEGEFPSIYSMLNDH-HS 327

  Fly   365 PLLATIVSGIFASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNVF 429
            |.:|.|...|.:|:..:..::..||..:|:|:.....:..|.:|.:|||:.::.:...|..|.:|
Mouse   328 PAVADIQIVILSSVAIISSSIIYLVKYVSLGSFCINLLQMIGLLKIRYQNPDIPRPYKVWLPFIF 392

  Fly   430 RQ-------FFNGNSFREPNSMTSSITKVGIVVFAIFCLVWC 464
            ..       .|.      |...:.||..|..||| :||...|
Mouse   393 GSIALSLFLIFT------PVIQSPSIEHVYQVVF-LFCGFLC 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	106/497 (21%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	94/474 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930