DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slif and slc7a2.2

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_017948087.1	Gene:	slc7a2.2 / 100494231	XenbaseID:	XB-GENE-5763997	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	626	Identity:	293/626 - (46%)
Similarity:	401/626 - (64%)	Gaps:	59/626 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NLWKALTRRKTEDVNEGE--SQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISF 65
            :.:|.|||.|...: |||  |.|.|.|:..||.|||||||||.|||||||:||...:||::.:||
Frog     9 SFYKILTRTKQVTL-EGENSSNLCRCLSTLDLVALGVGSTLGAGVYVLAGEVAKVDSGPSIILSF 72

  Fly    66 LIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGY 130
            ||||:||..||:|||||.||||..||||:|||||:||..||..||||||.|||||:||||..|..
Frog    73 LIAALASVLAGLCYAEFGARVPLTGSAYLYSYVTVGELWAFITGWNLILSYVIGTSSVARAWSAT 137

  Fly   131 FDSLINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTI 195
            ||.|:...:...|:.:||:|:..|.:|||..:..:::|||.:|:||.|||:.:|.:||.:|::.:
Frog   138 FDDLVGKKIGNFLSNTMHMDLPGLAEYPDIFAVCLIILLAGLLSFGVKESTTVNKVFTAINILVL 202

  Fly   196 AIVLVAGAMNANVDNWRIPKKDV--------------PEG--FGTGGFMPFGIAGVMAGAAKCFY 244
            ..|:.:|.:..|:..|::.|:|:              ..|  ||.|||||||.:|.:||||.|||
Frog   203 LFVIASGCVTGNIKYWKMSKEDLWVSKQTVSNHSIGNETGLDFGAGGFMPFGFSGTLAGAATCFY 267

  Fly   245 GFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDS 309
            .|||||||||||||..||:::|||.||:||.|.|.:|||||..||:|:||:..|..:|.|.||:.
Frog   268 AFVGFDCIATTGEEVKNPQKSIPLGIVLSLSICFFTYFGVSASLTLMMPYHLLDSQSPLPAAFEY 332

  Fly   310 VEWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGI 374
            |.|...|:||.:|::.||.|||||:|||:||||:||.:||:||:.||.::| .::|::||||||:
Frog   333 VGWSVAKYIVAVGSLCALTTSLLGSMFPMPRILFAMARDGLLFQPLSRLSS-RQSPVIATIVSGV 396

  Fly   375 FASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEEMTKLVSVKAPNVFRQFFNGNSFR 439
            .|::||.||:|..||||||||||||||:|:.|||:||||.:  |........|:..|  |.:|..
Frog   397 VAALMAFLFDLKALVDMMSIGTLLAYTLVSTCVLLLRYQPQ--TDFGKSPDGNLPEQ--NISSLS 457

  Fly   440 EPNSMTSSITKVGIV---VFAIFCLVWCSLQKVFDLDSTGG-------------IVALSLVGAVL 488
            .|.. |.|:....:|   |.||..|| |    |..:.||.|             ::.|||:|.:.
Frog   458 HPPE-TPSVHSSALVTHCVLAITLLV-C----VASVVSTAGSQCLLSGKAWCLSLLVLSLLGIIT 516

  Fly   489 ILICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFCYG 553
            .|  |:|..||.:..:.||.||.||.:|.:|:..|:|||.||..:||.|:.:|:.:|:||||.||
Frog   517 AL--VIIWRQPQNQSKATFMVPFVPVLPVVSILVNIYLMVQLSTDTWYRYAVWMAVGFVIYFGYG 579

  Fly   554 MRNSTQ-----------ISRSRSHAEVAASALQNQGQHVNP 583
            :|:|.:           ::.|.:.. ..|:.|:.|.....|
Frog   580 IRHSIERLQLMDKCTQKVAISSTETXCKANCLELQLGEAKP 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	286/582 (49%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	25/49 (51%)
slc7a2.2	XP_017948087.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm9394
Panther	1	1.100	-	-	O	PTHR43243
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160