DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and slc7a14

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_002931595.1	Gene:	slc7a14 / 100493085	XenbaseID:	XB-GENE-1010371	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	714	Identity:	259/714 - (36%)
Similarity:	377/714 - (52%)	Gaps:	146/714 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WKA---------LTRRKTEDVNEGE-------SQLARVLNLFDLTALGVGSTLGLGVYVLAGQVA 53
            |:|         |..:..|.:.||.       ::|||||...||.:|||||.:|.|:||::|.||
Frog    15 WRATWHAFSSRTLRTKPVESMLEGTAGTSAHGTKLARVLTTLDLVSLGVGSCVGTGMYVVSGMVA 79

  Fly    54 FNIAGPAVTISFLIAAIASAFAGICYAEFAARVPK-AGSAYVYSYVTIGEFVAFTIGWNLILEYV 117
            ..:|||.|.:||:|||:||..:|:|||||..|||| :||||.|||||:||||||.|||||:|||:
Frog    80 KEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTSGSAYTYSYVTVGEFVAFFIGWNLLLEYL 144

  Fly   118 IGTASVARGLSGYFDSLINNNMSKALNESMHIDVDFLG----DYPDFLSFGMVLLLAAILAFGAK 178
            |||||.|..||..||||.|..:|..:..::. .::.||    .||||::..:.:::..|:|.|.|
Frog   145 IGTASGASALSSMFDSLANYTISHWMITNVG-TLNGLGKGEDSYPDFIALVIAIIVTIIVALGVK 208

  Fly   179 ESSFLNNIFTTVNLVTIAIVLVAGAMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCF 243
            .|...||:...:|.:....:::||....|..||            :|.|:|:|.:|||.|||.||
Frog   209 NSVGFNNVLNVINFLVWIFIMIAGLFYVNGKNW------------SGDFLPYGWSGVMTGAATCF 261

  Fly   244 YGFVGFDCIATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFD 308
            |.|:|||.||||||||.:|..:||.:|..|||....:|..||.:||:.:||...|.::|....|.
Frog   262 YAFIGFDIIATTGEEAKSPNTSIPYAITASLITCLTAYVSVSVILTLAVPYNMIDTESPLMEMFV 326

  Fly   309 SVEWYTIKWIVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSG 373
            ...:|..|::|.:|:|..|..||.|::||:||::|||..||:|||.|:.|:|||:||::|.:|||
Frog   327 VHGFYAAKFVVAVGSVAGLTVSLFGSLFPMPRVIYAMAGDGLLFKFLAHVSSYTETPVVACVVSG 391

  Fly   374 IFASIMAMLFNLDQLVDMMSIGTLLAYTIVAICVLVLRYQDEE----MTKLVSVK---------- 424
            ..|.::::|.:|..|::|||||||||||:|::|||:||||.|.    ..|.:|.:
Frog   392 FLAGLLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFISEENTKKKEGILA 456

  Fly   425 -------APNVFRQFFNG----------------------------NSFREPN----SMTSSITK 450
                   :|....:.|:|                            .:...||    .|||.|..
Frog   457 DCEKDACSPMSDGEEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSHYNINHPNYGTVDMTSGIEA 521

  Fly   451 VG--------------------------------------------IVVFAIFCLVWCSLQKVFD 471
            .|                                            :::..:..|::||. .:|.
Frog   522 DGSENRYLFKIKKFIGPRYYTLRIRLGLPGKMDRPTAATGRTVTICVILLFLLILIFCSF-IIFA 585

  Fly   472 LD-----STGGIVALSLVGAVLILICVVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLD 531
            .|     :...|:.:.|:..:|..:..||..||.:..:|.:..|.|||||..::..|:|||.:|.
Frog   586 ADYIYEQAWWAILLVVLMVLLLFALVFVILQQPENPKKLPYMAPCVPFVPAFAMLVNVYLMLKLS 650

  Fly   532 LNTWIRFLIWIVIGYVIYFCYGMRNST-QISRSRSHAEVAASALQNQGQHVNPGFEPDYKVENG 594
            ..|||||.||..:|.:|||.|||.||| :||        |...:.:|..:.....:.::.|::|
Frog   651 SITWIRFAIWCFVGLLIYFGYGMWNSTLEIS--------AREEVLHQSTYQRYDVDDNFSVDDG 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	248/662 (37%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	25/49 (51%)
slc7a14	XP_002931595.1	2A0303	20..676	CDD:273330	248/669 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439017at2759
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010