DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and slc7a3

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_012823434.1	Gene:	slc7a3 / 100144737	XenbaseID:	XB-GENE-1002485	Length:	619	Species:	Xenopus tropicalis

Alignment Length:	610	Identity:	296/610 - (48%)
Similarity:	398/610 - (65%)	Gaps:	47/610 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KALTRRKTEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTISFLIAAI 70
            |.|.||:..|..:.|:..||.|...||||||||||||.|||||||:||...|||::.:.||.||:
Frog    12 KKLLRRRVIDFGDKETGFARCLTTLDLTALGVGSTLGAGVYVLAGEVAKKSAGPSIVLCFLAAAL 76

  Fly    71 ASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLI 135
            :|..||:|||||.|||||.||||:|||||:||..|||.||||||.||:|||||||..|..||::|
Frog    77 SSVLAGLCYAEFGARVPKTGSAYLYSYVTVGEIWAFTTGWNLILSYVLGTASVARAWSSTFDNII 141

  Fly   136 NNNMSKALNESMHIDVD-FLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVTIAIVL 199
            .:::|.....::...:: .|.:||||.:..:|:||.|:||||..||:.:|.|||.:||:.:|.|:
Frog   142 GSHISTFFKANISFKMENILAEYPDFFALILVMLLTALLAFGVSESALVNKIFTAINLLVLAFVI 206

  Fly   200 VAGAMNANVDNWRIPKKDVPE------------GFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCI 252
            |:|.:..::.||.:.::|...            .||:|||.|||..||..|||.|||.|||||||
Frog   207 VSGFVKGDLKNWTLTEEDYENITKELQNSTNIGSFGSGGFTPFGFGGVATGAAACFYAFVGFDCI 271

  Fly   253 ATTGEEAINPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKW 317
            |||||||.||:::||:||::||::.|::|||||..||:|:||:..:||:|.|.||..|.|...::
Frog   272 ATTGEEAKNPQKSIPISIIISLLVCFVAYFGVSAALTLMMPYFLLNKDSPLPDAFKYVGWEPARY 336

  Fly   318 IVTIGAVFALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAML 382
            ||.||::.||.|||||:|||:||::|||.:||:|||.|:.||..|:|||:||||||:.::|||.|
Frog   337 IVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKVNKRTQTPLIATIVSGVISAIMAFL 401

  Fly   383 FNLDQLVDMMSIGTLLAYTIVAICVLVLRYQ------DEEMTKL--------VSVKAPN---VFR 430
            |.|:.||::|||||||||::||.||.:||||      |.||.||        .:...|.   ..:
Frog   402 FELEVLVELMSIGTLLAYSLVAACVAILRYQPDQPCSDTEMEKLNGEECEREAATSEPEKSFQMK 466

  Fly   431 QFFNGNSFREPNSMTSSITKVGIV-----VFAIFCLVWCSLQKVFDLDSTGGIVALSLVGAVLIL 490
            ...|.:....| |.||.....|.|     ||...||:   |.:..|....|..:.:||. |:|.|
Frog   467 HLLNIDCDASP-SKTSGHIVYGCVSLISFVFIFLCLI---LAQKIDAILEGSALWISLC-AILSL 526

  Fly   491 IC----VVIGMQPVSTIELTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFC 551
            |.    :||..||.:...|.||||.:|.:|..|||.|||.|.||:..||:|||:|:.||::|||.
Frog   527 IAFGITIVIWRQPENKTRLNFKVPALPVLPLFSVFINLYFMMQLNAWTWVRFLVWMAIGFLIYFI 591

  Fly   552 YGMRNSTQISRSRSHAEVAASALQN 576
            ||:|||.:...|:   |..::.:.|
Frog   592 YGVRNSVEEKNSK---EKTSNTIYN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	290/587 (49%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	29/49 (59%)
slc7a3	XP_012823434.1	2A0303	7..599	CDD:273330	293/591 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	459	1.000	Domainoid score	I483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm9394
Panther	1	1.100	-	-	O	PTHR43243
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160