DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F3 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	167/551 - (30%)
Similarity:	260/551 - (47%)	Gaps:	103/551 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    19 WL---LLLLVGASWLL------ARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGL-------- 66
            ||   ||||..:.:||      :||...|:.          :|.||... |:|||.:
  Fly     3 WLGFGLLLLALSLYLLYVFERQSRIDRLTHK----------WPAPPALP-FIGHLHILAKLVGPH 56

Human    67 ------------IHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVP 119
                        :|.....|                |:|....:|.. :|..|:.:..|...:..
  Fly    57 PLRRATEMINEHLHDHRAKL----------------WMGTKLYLVDC-NPKDIQALCSAQQLLQK 104

Human   120 KDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
            .:.  |...:.||.:||..|..||||..|:::.|||::.::|.::.:|.:...|:.......|..
  Fly   105 TND--YRVFENWLCEGLFTSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAES 167

Human   185 GSARLDMFEHISLMTLDSLQKCVF--SFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLY 247
            |. ::|..:.||..|||::.:...  |..|....| |||:.|:..:..::.||.:.|.....|::
  Fly   168 GD-QIDFLQLISCFTLDTICETALGVSVGSQSSAK-SEYLDAVKSILVIIDKRLKNIFYRNSFIF 230

Human   248 YLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQ-AKAKS------------KTLDFI 299
            ..|...:|.:...:.:|.||:.:||:|        :|:..| |:.::            :||.|:
  Fly   231 KRTSHYKREQELIKTLHGFTEGIIQKR--------IDEINQDAENRNYQSSDAELDGVKRTLCFL 287

Human   300 DVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL-K 363
            |.|||||..|||.|:.:|||.|.||.:|.|.|.||:.|::.:|::..|||:|:|||:||..:. |
  Fly   288 DTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGK 352

Human   364 DR-EPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGT 427
            |: ||..||  .:.||.||..||||:||::|..|..:|..|.:..:.| ..||||...:||....
  Fly   353 DKSEPISIE--QVRQLEFLEACIKETLRMYPSGPLTARKATANCTIND-FFIPKGSDVIISPIYM 414

Human   428 HHNPAVWPDPEVYDPFRF----DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLR 488
            ......:|||.|:.|.|:    :||    .....||||.||.|:|:||.:||..:|:||...|..
  Fly   415 GRCKDFFPDPMVFKPDRWAIGAEPK----IEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRN 475

Human   489 FRVLPDHTEPRRKPELVLRAEGGLWLR-VEP 518
            |..     ||..:.::.|:....:.|. |||
  Fly   476 FLF-----EPLGERQVKLKLNFVITLHTVEP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	152/503 (30%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	156/509 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750