Protein Alignment CYP4F3 and Cyp4d8

DIOPT Version :9

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 169/547 - (30%)
• Similarity: 260/547 - (47%)
• Gaps: 107/547 - (19%)

Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTF 84
            |::||.||.|::                               |||....       .:.:|...
  Fly     6 LVVLLFGAGWII-------------------------------HLGQADR-------RRKVANLP 32

Human    85 GDMCCWWVGPWHAIVRIFHPTYIK--------------PVLFAPAAIVPKDKVF----------- 124
            |.:|...:|....::|:...|:||              ..:|....|:..|...
  Fly    33 GPICPPLIGAMQLMLRLNPKTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHL 97

Human   125 -----YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE 184
                 |..|..|||:|||||.|:.|.:.|:::||.|||:||:.::::|::..||.   .|.||.:
  Fly    98 VKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQK 159

Human   185 GSAR-LDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLY 247
            .:.. .|::..|....||.:.:.......:.|...| .|..|:.|.:||::.|...:.|.::.|:
  Fly   160 ANGNTFDVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLF 224

Human   248 YLTPDGQRFRRA--CRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLD------------- 297
            .||....::|:.  .|.:.:||..||::||:.|..|          :||.:|
  Fly   225 TLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQ----------QSKLMDTADEDVGSKRRMA 279

Human   298 FIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362
            .:||||:| ..||:.|::::||.|.|||||||||||.|.||:.|:.|::|||.|.:..:|:.::|
  Fly   280 LLDVLLMS-TVDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVL 343

Human   363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDI-----VLPDGRVIPKGIICLI 422
            .....:.:...||.:|.::...||||||::||||.|.|....|.     |..|| |||.|...:|
  Fly   344 GTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIII 407

Human   423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL 487
            .:||.|..|..:|:|:.:.|.|.:  |....:|...|||||||||||||.||..|||::|...:.
  Fly   408 GIFGVHRQPETFPNPDEFIPERHE--NGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR 470

Human   488 RFRVLPDHTEPRRKPELVLRAEGGLWL 514
            .:.:||..........:|||:|.|..|
  Fly   471 EYELLPMGQRVECIVNIVLRSETGFQL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	163/515 (32%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	151/447 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750