Protein Alignment CYP4F3 and Cyp4d20

DIOPT Version :9

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 162/530 - (30%)
• Similarity: 252/530 - (47%)
• Gaps: 101/530 - (19%)

Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTF 84
            |..|.:||.    .|:.|....:|...:...|       |.||         |.|:||:.|
  Fly    46 LQALHLGAE----NIIGWVGEKFDKYGKTFRF-------WILG---------ESLIYTKDL---- 86

Human    85 GDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRR 149
                                .|.:.:| :...::.|.:: |.:|:|:|.||||:|.|.||...|:
  Fly    87 --------------------QYFETIL-SSTTLLEKGQL-YEYLRPFLNDGLLVSTGRKWHARRK 129

Human   150 MLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHC 214
            :.|.||||.:|:.|::|.:...::|....:.:| :|...:||.:::||..||.:.:.......:.
  Fly   130 IFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVA-DGKTAVDMLKYVSLAALDVITEAAMGVQVNA 193

Human   215 QEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQ-RFRRA------------------ 259
            |..|. .||.|   |.::|               |:.||.. ||.|.
  Fly   194 QNDPDFPYIKA---LKSVV---------------YIQPDRMFRFSRRYNWLFPLAAPLLHRQLLS 240

Human   260 -CRLVHDFTDAVIQERRRTL----------PSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKL 313
             .|::|||||.||.|||.|:          |....|..:.:|::...||    :||....:.:.|
  Fly   241 DIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----ILLQSSINNQPL 301

Human   314 SDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQL 378
            ||.|||.|.|||||||.|||:||:|..||.:|:|||.|:|..:|:|.:|.......:....|..|
  Fly   302 SDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDL 366

Human   379 PFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPF 443
            .:|...|||::||:|||||:.|...:::.:.| :.||......:.::..|.:...:|||..:.|.
  Fly   367 KYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPE 430

Human   444 RFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRA 508
            ||.....:..:..|::||||||:|||||.||:.||||::...|..:.:||...|.:.....:||:
  Fly   431 RFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRS 495

Human   509 EGGLWLRVEP 518
            ..|:.:.:.|
  Fly   496 ASGINVGLRP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	153/493 (31%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	158/516 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750