DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F3 and Cyp6a21

DIOPT Version :9

Sequence 1:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_611003.2	Gene:	Cyp6a21 / 36665	FlyBaseID:	FBgn0033981	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	134/561 - (23%)
Similarity:	232/561 - (41%)	Gaps:	133/561 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    21 LLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSL----- 80
            ||.|||  :||   :.|..|.               |:|  ..||:  ..||..:...|:
  Fly    11 LLALVG--YLL---MKWRSTM---------------RHW--QDLGI--PCEEPHILMGSMKGVRT 51

Human    81 ACTFGDMCCWWV---------GP-----WHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLK-- 129
            |.:|.::   |.         ||     |          :.:|.:|.....:.|..:...|.|
  Fly    52 ARSFNEI---WTSYYNKFRGSGPFAGFYW----------FRRPAVFVLETSLAKQILIKEFNKFT 103

Human   130 -----------PWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYM-----KIFNESVNIMHAKW 178
                       |..|. |.|..|:||...|..|:..|....:| ||     |:.||..::.   .
  Fly   104 DRGFFHNPEDDPLSGQ-LFLLDGQKWRTMRNKLSSTFTSGKMK-YMFPTVVKVANEFTDVF---G 163

Human   179 QLLASEGSARLDMFEHISLMTLDSLQKCVFSFD-SHCQEKPSEY-----------------IAAI 225
            |.:|.  |..:::.|.::..|.|.:..|.|..: |..::..:|:                 |..:
  Fly   164 QNVAK--SPVVEVRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFV 226

Human   226 LELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAK 290
            .....|..:.|.::.        ..|..:.|.|..|     .....:|:.....:..:|..:..|
  Fly   227 NSFPNLARRLHMKMT--------AEPIERFFMRIVR-----ETVAFREQNNIRRNDFMDQLIDLK 278

Human   291 AKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCR 355
            .|.        |::|:..:...|:.|:|.|:|..|...|.:|:::.:.:.||.||::.:.|.|.|
  Fly   279 NKP--------LMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVR 335

Human   356 QEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGR---VIPKG 417
            :|.||:: ::...|:.::.:..|.:|...:.|:|||:..:|.::|.|.:|..:| |.   ||.||
  Fly   336 KECQEVI-EKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVP-GHPKYVIKKG 398

Human   418 IICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482
            :..||.....|.:..::.:|..::|..|.|:.:|||..:.::||..|||||||..|  .:|:..:
  Fly   399 MPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRF--GQMQARI 461

Human   483 GLTLL----RFRVLPDHTEPR--RKPELVLRAEGGLWLRVE 517
            ||.||    :|.|....|.|.  .|...::.:..|::|:.|
  Fly   462 GLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	123/526 (23%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	119/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810