Protein Alignment CYP4F3 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 149/528 - (28%)
• Similarity: 247/528 - (46%)
• Gaps: 65/528 - (12%)

Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSE--EGLL---YTQS 79
            ||.|:||...|:|..:...||::    :.|..|..|. |..||:.|.:..:.  .|:|   |.:.
  Fly     4 LLGLVVGVLTLVAWWVLQNYTYW----KRRGIPHDPP-NIPLGNTGELWRTMPLAGILKRTYLKF 63

Human    80 LACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDK-----VFYSFLKPWLGDGLLLS 139
            ...|.|....:::.....|| |....::|.||     |...||     |:::.....|.:.|...
  Fly    64 RKQTDGPFAGFYLYAMKYIV-ITDVDFVKTVL-----IRDFDKFHDRGVYHNEKDDPLTNNLATI 122

Human   140 AGEKWSRHRRMLTPAFHF----NILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTL 200
            .|:||...|:.||..|..    ::....:.:.:|.:.::..|    .|..|..|::.:.:|..|.
  Fly   123 EGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEK----ISSSSQTLEVTDIVSRFTS 183

Human   201 DSLQKCVFSFDSHCQEKP-SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVH 264
            |.:..|.|....:....| :|::.  :..|||..:||..:   :|.|.:..|     :.|.:|..
  Fly   184 DVIGICAFGLKCNSLRDPKAEFVQ--MGYSALRERRHGWL---VDLLIFGMP-----KLAVKLGF 238

Human   265 DFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSK---DEDGKK--LSDEDIRAEADT 324
            .|....:|:....:....:|  .:.|.|....||:|.|:..|   |:..|:  |:..::.|:|..
  Fly   239 QFLLPSVQKFYMKIVQDTID--YRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFV 301

Human   325 FMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESL 389
            |...|.:..::.:.:.||.||.:.:.|::.|.|:..:| :|...::|:|.:..|.::...|.|||
  Fly   302 FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVL-ERYNGKLEYDSMQDLFYMEKVINESL 365

Human   390 RLHPPVPAVSRCCTQDIVLPDGRVIPK-----GIICLISVFGTHHNPAVWPDPEVYDPFRFDPKN 449
            |.||.|..::|..|:    |.....||     |...|:|..|.||:|..:|:||.:.|.|||.:.
  Fly   366 RKHPVVAHLARIATK----PYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQ 426

Human   450 IKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL----RFRVLPDHTEPRRKP--ELVLRA 508
            :|:|...||:||.||||||||..|  ..|:|::||.||    ||.:.|....|.:..  .|:|.:
  Fly   427 VKKRPTCAFLPFGAGPRNCIGLRF--GRMQVIIGLALLIHNFRFELHPKTPVPMKYTINNLLLGS 489

Human   509 EGGLWLRV 516
            |||:.|.:
  Fly   490 EGGIHLNI 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	138/493 (28%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	138/492 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810