Protein Alignment CYP4F3 and Cyp6a23

DIOPT Version :10

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 139/554 - (25%)
• Similarity: 234/554 - (42%)
• Gaps: 112/554 - (20%)

Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTF 84
            |:.|||.....:||                      :|:.:....|:.|.....:         :
  Fly     7 LIALLVSLLLFMAR----------------------RRHGYWQRRGIPHDVPHPI---------Y 40

Human    85 GDMCCWWVGPWHAIVRIFHPTYIK------P-----VLFAPAAIVP----------KD------- 121
            |:|..|  .....|..||...|.|      |     ..|..:|::.          ||
  Fly    41 GNMKDW--PKKRHIAMIFRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENR 103

Human   122 KVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHF----NILKPYMKIFNESVNIMHAKWQLLA 182
            .:||:.:...|...|....|:||...|..|||.|..    |:....:|:..|...|..||  ...
  Fly   104 GIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAK--TTT 166

Human   183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVTKRHQQILLYIDFL 246
            .||.. |::.:.::..|.|.:..|.|..:.:..:.| :|::.  :...|::.:|:..:|   |||
  Fly   167 GEGQV-LEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVT--IGKRAIIERRYGGLL---DFL 225

Human   247 YYLTPDGQRFRRACRL------VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLL-- 303
            .:..|   :..|..||      |.||..:::   |.|:      |: :.:...|..||:|.|:
  Fly   226 IFGFP---KLSRRLRLKLNVQDVEDFYTSIV---RNTI------DY-RLRTNEKRHDFMDSLIEM 277

Human   304 -----LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363
                 ....|||  ||..:|.|:|..|...|.:|:::.:.:.||.||...:.|::.|.|:..:|
  Fly   278 YEKEQAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL- 339

Human   364 DREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGR-VIPKGIICLISVFGT 427
            .:...|..::.:.::.:|...:.|:||.:|.:..::|....|....|.: .|.||...:|...|.
  Fly   340 SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGI 404

Human   428 HHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL----R 488
            |::|.::|:||.:.|.||..:.|..|....::||..|||||||..|.:  |:..:||..|    :
  Fly   405 HYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGL--MQACVGLAYLIRGYK 467

Human   489 FRVLPDHTEPRR--KPELVLRAEGGLWLRVEPLS 520
            |.|..:...|.:  ...::|.||.|:.|:||.||
  Fly   468 FSVSTETQIPMKFVVKSILLSAENGIHLKVEKLS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	125/493 (25%)
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	117/451 (26%)