Protein Alignment CYP4F3 and Cyp4d21

DIOPT Version :10

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_609129.2
• Gene: Cyp4d21 / 34036
• FlyBaseID: FBgn0031925
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 477
• Identity: 152/477 - (31%)
• Similarity: 240/477 - (50%)
• Gaps: 57/477 - (11%)

Human    57 RNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD 121
            |.|.||         |.|:||:.|                        .|.:.:|.:...:  |.
  Fly    72 RLWILG---------ECLIYTKDL------------------------KYFESILSSSTLL--KK 101

Human   122 KVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGS 186
            ...|.||:.:||||||||.|.||:..|::|.|||||..|:.:::|.:.:..||..|.:..| :|.
  Fly   102 AHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYA-DGK 165

Human   187 ARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLT 250
            ..:|:|:.:||..||...:.......:.|.:|: .|..|:..:..:.:||...:.:..::|:.|.
  Fly   166 TCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLA 230

Human   251 PD--GQRFRRACRLVHDFTDAVIQERRRTLP---SQGV-------DDFLQAKAKSKTLDFIDVLL 303
            ..  .:|.::...::.||||.||:|||..|.   :.|.       ||.:..|||...||    :|
  Fly   231 APLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLD----IL 291

Human   304 LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPK 368
            |....|.|.|||.|||.|.|.|:|.|.|||.||:|..|:.:::||:.||...:|:..:|......
  Fly   292 LQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDA 356

Human   369 EIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKGIICLISVFGTHHNPA 432
            .:....|.:|.:|...|||::|||||||.:.|...:|:.:  |.: ||.....|:..:..:.:|.
  Fly   357 SVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKI--GEITIPGNTSILLMPYYVYRDPE 419

Human   433 VWPDPEVYDPFRF-DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHT 496
            .:|||.|:.|.|: |.|......|||:||||:||:|||||.||..:||.::...:..:.:||...
  Fly   420 YFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGA 484

Human   497 EPRRKPELVLRAEGGLWLRVEP 518
            :.:.....:|.:..|..:.::|
  Fly   485 DLKATYTFILSSSTGNNVGLKP 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	146/455 (32%)
Cyp4d21	NP_609129.2	CYP4	68..502	CDD:410721	151/471 (32%)