DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F3 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	169/528 - (32%)
Similarity:	260/528 - (49%)	Gaps:	61/528 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLL----LLVGASWLLARILAWTYTFYDNCCRLR----------CFPQPPKRNWFLGHLGLIHS 69
            |:.|    ||:||.|||.|.|..||.....|.|:|          .|..|.|.. |..:|.|::.
  Fly     2 WIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTR-FGNNLDLLNL 65

Human    70 SEEGLL--YTQSLACTFGDMCCW--WVGPWHAIVR------IFHPTYIKPVLFAPAAIVPKDKVF 124
            :...:.  ..:|.|...|....|  ...|.:.|||      ||..|.|           ....:.
  Fly    66 TPANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKI-----------TTKNMS 119

Human   125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKW-QLLASEGSAR 188
            |..::|:||||||:|..:||...|:.||||||||||:.::.||.|.    ..|: ::|.......
  Fly   120 YELIRPFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE----SKKFIKILDKNVGFE 180

Human   189 LDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDG 253
            |::.:.|...||:::.:...........:.:||..||.:...:..:|....|::.::.::|..|.
  Fly   181 LELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDY 245

Human   254 QRFRRACRLVHDFTDAVIQERRRTLPSQ---GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSD 315
            :::.|..|.:|.|:..:||.:|:....:   .||:|    .|.:....:|.||.::.|.  |:..
  Fly   246 KKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEF----GKKQRYAMLDTLLAAEAEG--KIDH 304

Human   316 EDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380
            :.|..|.:||||.|:|||::.|.:.|..||.|.:.||||.:|:|:|.:|.:  |:......:|..
  Fly   305 QGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDID--EVSMFQFNELIH 367

Human   381 LTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445
            |...|||||||.|..|.:.|.|.::.|: :|.|:||.....|.::....:...:|.|..:.|.||
  Fly   368 LECVIKESLRLFPSAPIIGRTCIEESVM-NGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERF 431

Human   446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLP-DHTEPRRKPELVLRAE 509
            .|:|...|.|.||:||||||||||||.|.:.|:||:|...:..|::|| ...|.       |..|
  Fly   432 LPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPATQLED-------LTFE 489

Human   510 GGLWLRVE 517
            .|:.||.:
  Fly   490 NGIVLRTQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	150/477 (31%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	152/479 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850