DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP4F3 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	162/524 - (30%)
Similarity:	268/524 - (51%)	Gaps:	53/524 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    19 WLLLL----LVGASWLLARILAWTYTFYDNCCRLRCFP-QP--------PKRNWFLGHLGLIHSS 70
            |:.||    |:....||.:.:..||.......|:|... .|        |.:..|..:|.:::.:
  Fly     2 WIALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFT 66

Human    71 EEGL--LYTQSLACTFGDMCCWW--VGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPW 131
            ...:  ...:|.|...|....|:  ..|.:.:||   |...:.| |....::.|: |.|..::|:
  Fly    67 PASVFNFVRESTAKAKGQNYLWYFLYAPMYNVVR---PEEAEEV-FQSTKLITKN-VVYELIRPF 126

Human   132 LGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNES----VNIMHAKWQLLASEGSARLDMF 192
            ||||||:|...||...|:.||||||||:|:.::.||.|.    :|:       |.....|.|::.
  Fly   127 LGDGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNV-------LEKNLDAELELN 184

Human   193 EHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFR 257
            :.|...||:::.:...........:.:||..||..:..::.:|....|:|.::.:::..|.::..
  Fly   185 QVIPPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFFVYGDYRKHL 249

Human   258 RACRLVHDFTDAVIQERRRTLPSQ---GVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIR 319
            :..|:||||:..:|:.:|:....:   .||:| ..|.:...||    .||:.:.|| ::..:.|.
  Fly   250 QNLRIVHDFSSRIIERKRQQFQQKQLGEVDEF-GRKQRYAMLD----TLLAAEADG-QIDHQGIC 308

Human   320 AEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMC 384
            .|.:||||||:|||::.|.:.|..||.|.:.|::|.:||:.|.:|.:  :|......:|.:|...
  Fly   309 DEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSD--DISMFQFNKLVYLECV 371

Human   385 IKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKN 449
            ||||||:.|.||.:.|.|.::.|: :|.|:||.....|.::....:|..:|.|:::.|.||.|:|
  Fly   372 IKESLRMFPSVPFIGRQCVEETVV-NGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLPEN 435

Human   450 IKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLP-DHTEPRRKPELVLRAEGGLW 513
            ...|.|.|::|||||.||||||.||:.||||:|...:..|::|| ...|.       |..|.|:.
  Fly   436 TVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLED-------LTFENGIV 493

Human   514 LRVE 517
            ||.:
  Fly   494 LRTQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	150/483 (31%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	145/440 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850