Protein Alignment CYP4F3 and Cyp4d1

DIOPT Version :10

• Sequence 1: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 441
• Identity: 156/441 - (35%)
• Similarity: 253/441 - (57%)
• Gaps: 25/441 - (5%)

Human    91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKV-FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPA 154
            |:|| ...|.:.:|..::.||   ..:...||. .|..|:|||.:|||:|.|.||.:.|:::|||
  Fly    77 WLGP-ELNVLMGNPKDVEVVL---GTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPA 137

Human   155 FHFNILKPYMKIFNE-SVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEK- 217
            |||.||..::::|.: |.:::....|.....|.:...:::.|:|.|:|::.:.......:.|..
  Fly   138 FHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNA 202

Human   218 PSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQG 282
            .|||:.|:..:|.::.||...||...|..|.|||..:..::|..::|.||:.:|.:||..|..:|
  Fly   203 DSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREG 267

Human   283 -----VDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLY 342
                 .:|.....||.| :.|:|:||.| ..|.:.||:.|||.|.|||||||||||:|.|.:..|
  Fly   268 SSQESSNDDADVGAKRK-MAFLDILLQS-TVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFY 330

Human   343 HLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIV 407
            ::|.|||.|::|.:|::.::.:.:...:.::.|.||.::.:|:||:||::|.||.:.|...:|..
  Fly   331 NIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCE 395

Human   408 LPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKER-SPLAFIPFSAGPRNCIGQ 471
            : :|::||.|....||.........::.:|.::.|.|||.....|: :|.|:|||||||||||||
  Fly   396 I-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQ 459

Human   472 AFAMAEMKVVLGLTLLRFRV--LPDHTEPRRKP----ELVLRAEGGLWLRV 516
            .|||.|:|.::...|..:.|  :.|.:||   |    ||:||.:..|..:|
  Fly   460 KFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKEPLMFKV 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	155/438 (35%)
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	154/436 (35%)