DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP4F3 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	156/441 - (35%)
Similarity:	253/441 - (57%)	Gaps:	25/441 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    91 WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKV-FYSFLKPWLGDGLLLSAGEKWSRHRRMLTPA 154
            |:|| ...|.:.:|..::.||   ..:...||. .|..|:|||.:|||:|.|.||.:.|:::|||
  Fly    77 WLGP-ELNVLMGNPKDVEVVL---GTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPA 137

Human   155 FHFNILKPYMKIFNE-SVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEK- 217
            |||.||..::::|.: |.:::....|.....|.:...:::.|:|.|:|::.:.......:.|..
  Fly   138 FHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNA 202

Human   218 PSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQG 282
            .|||:.|:..:|.::.||...||...|..|.|||..:..::|..::|.||:.:|.:||..|..:|
  Fly   203 DSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREG 267

Human   283 -----VDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLY 342
                 .:|.....||.| :.|:|:||.| ..|.:.||:.|||.|.|||||||||||:|.|.:..|
  Fly   268 SSQESSNDDADVGAKRK-MAFLDILLQS-TVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFY 330

Human   343 HLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIV 407
            ::|.|||.|::|.:|::.::.:.:...:.::.|.||.::.:|:||:||::|.||.:.|...:|..
  Fly   331 NIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCE 395

Human   408 LPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKER-SPLAFIPFSAGPRNCIGQ 471
            : :|::||.|....||.........::.:|.::.|.|||.....|: :|.|:|||||||||||||
  Fly   396 I-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQ 459

Human   472 AFAMAEMKVVLGLTLLRFRV--LPDHTEPRRKP----ELVLRAEGGLWLRV 516
            .|||.|:|.::...|..:.|  :.|.:||   |    ||:||.:..|..:|
  Fly   460 KFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKEPLMFKV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	155/438 (35%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	155/439 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750