DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssl1 and gtf2h2

DIOPT Version :9

Sequence 1:	NP_001262227.1	Gene:	Ssl1 / 40509	FlyBaseID:	FBgn0037202	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_963875.1	Gene:	gtf2h2 / 323239	ZFINID:	ZDB-GENE-030131-1959	Length:	392	Species:	Danio rerio

Alignment Length:	405	Identity:	203/405 - (50%)
Similarity:	271/405 - (66%)	Gaps:	17/405 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQEDQKEYRWETGYEKTWEAIKDDEDGMLDGAIAEIIQKAKRQRQAQKSKQNRLGMMRHMFVVLD 69
            ::|.::..|||.|||:|||.:|:||.|.|...:.:|:.:|||:|..:...|.|||||||:||::|
Zfish     2 DEEPERTKRWEGGYERTWEVLKEDESGSLKATVEDILFQAKRKRVFESHGQVRLGMMRHLFVIID 66

  Fly    70 CSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGTSRVHLKAL 134
            .|.||...||||.||..|:||:|.|:||:||||||||:|:|..|.|||||:|:|.|..:.|:.||
Zfish    67 SSRSMEDQDLKPNRLTSTLKLMEHFVEEYFDQNPISQIGIITTKNKRAEKLTDLAGNPKKHITAL 131

  Fly   135 ESLANVSLTSEPSLQNGLDLALKSLKVVPSHASREIVIIMGSLTTCDPVDINLTIDELKKEGIRC 199
            ....:.:...||||.|.|::||::||.:|:|.|||:::|..|||||||.:|...|..|....||.
Zfish   132 RKAVDSTCVGEPSLYNSLNMALQTLKHMPAHTSREVLVIFSSLTTCDPGNIYELIKTLNGLKIRV 196

  Fly   200 SVISLSAEIHVARYLTQQTMGTFGAVLDDAHFRDQLMSQVDPPPAAKTQHNSLIRMGFP-HTKNE 263
            |||.||||:.|...||::|.|::..:||::||::.|:..|.||||:.:...|||||||| |....
Zfish   197 SVIGLSAEVRVCTILTRETGGSYNVILDESHFKELLLLHVKPPPASSSSECSLIRMGFPQHVIAS 261

  Fly   264 VEGKDAPLSMCMCHIENLEEPSELTTTGHHCPQCNSKYCELPVECQSCGLTLVSAPHLARSYHHL 328
            :..:||..|..|.|:::..|| ||:..|::||||.:||.||||||:.||||||||||||||:|||
Zfish   262 LSDQDAKPSFSMAHLDSSSEP-ELSLGGYYCPQCRAKYTELPVECKVCGLTLVSAPHLARSFHHL 325

  Fly   329 FPVPNFEELPFEAMPASSSDLTSDVRECYGCAKALGQGVDKVADKVVFRCGFCKQFFCVDCDIFI 393
            ||:..|:|.|.|.....        |.|..|     ||  ::.||.||.|..||:.|||:|||||
Zfish   326 FPLEAFQETPLEEYEGE--------RFCEAC-----QG--ELKDKSVFTCLACKKVFCVECDIFI 375

  Fly   394 HDTLHACVGCNTIPG 408
            |||||.|.||..|.|
Zfish   376 HDTLHCCPGCMQIDG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssl1	NP_001262227.1	SSL1	10..407	CDD:227480	200/397 (50%)
		Ssl1	67..258	CDD:190848	95/190 (50%)
		C1_4	291..403	CDD:297864	62/111 (56%)
gtf2h2	NP_963875.1	vWA_transcription_factor_IIH_type	56..240	CDD:238730	93/183 (51%)
gtf2h2	NP_963875.1	C1_4	288..385	CDD:297864	62/111 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580661
Domainoid	1	1.000	197	1.000	Domainoid score	I3069
eggNOG	1	0.900	-	-		E1_COG5151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1159
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1881
OMA	1	1.010	-	-		QHG54264
OrthoDB	1	1.010	-	-		D285146at33208
OrthoFinder	1	1.000	-	-		FOG0004477
OrthoInspector	1	1.000	-	-		oto38645
orthoMCL	1	0.900	-	-		OOG6_102284
Panther	1	1.100	-	-	LDO	PTHR12695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1505
SonicParanoid	1	1.000	-	-		X3170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800