DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssl1 and Gtf2h2

DIOPT Version :9

Sequence 1:	NP_001262227.1	Gene:	Ssl1 / 40509	FlyBaseID:	FBgn0037202	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001347635.1	Gene:	Gtf2h2 / 23894	MGIID:	1345669	Length:	398	Species:	Mus musculus

Alignment Length:	405	Identity:	205/405 - (50%)
Similarity:	272/405 - (67%)	Gaps:	17/405 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQEDQKEYRWETGYEKTWEAIKDDEDGMLDGAIAEIIQKAKRQRQAQKSKQNRLGMMRHMFVVLD 69
            ::|.::..|||.|||:|||.:|:||.|.|...|.:|:.||||:|..:...|.|||||||::||:|
Mouse     2 DEEPERTKRWEGGYERTWEILKEDETGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVD 66

  Fly    70 CSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGTSRVHLKAL 134
            .|.:|...||||.||.||:||||.|:||:||||||||:|:|..|:|||||:|||:|..|.|:.:|
Mouse    67 GSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSL 131

  Fly   135 ESLANVSLTSEPSLQNGLDLALKSLKVVPSHASREIVIIMGSLTTCDPVDINLTIDELKKEGIRC 199
            :...:::...||||.|.|.:|:::||.:|.|.|||::||..|||||||.:|...|..||...||.
Mouse   132 KKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRV 196

  Fly   200 SVISLSAEIHVARYLTQQTMGTFGAVLDDAHFRDQLMSQVDPPPAAKTQHNSLIRMGFP-HTKNE 263
            |||.||||:.|...|.::|.||:..:||:.|:::.|...|.||||:.:...|||||||| ||...
Mouse   197 SVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLAHHVSPPPASSSSECSLIRMGFPQHTIAS 261

  Fly   264 VEGKDAPLSMCMCHIENLEEPSELTTTGHHCPQCNSKYCELPVECQSCGLTLVSAPHLARSYHHL 328
            :..:||..|..|.|::|......||..|:.||||.:|||||||||:.||||||||||||||||||
Mouse   262 LSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHL 326

  Fly   329 FPVPNFEELPFEAMPASSSDLTSDVRECYGCAKALGQGVDKVADKVVFRCGFCKQFFCVDCDIFI 393
            ||:..|:|:..|.....        |.||||     ||  ::.|:.|:.|..|:..||||||:|:
Mouse   327 FPLDAFQEISLEEYKGE--------RFCYGC-----QG--ELKDQHVYVCTVCQNVFCVDCDVFV 376

  Fly   394 HDTLHACVGC-NTIP 407
            ||:||.|.|| :.||
Mouse   377 HDSLHCCPGCIHKIP 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssl1	NP_001262227.1	SSL1	10..407	CDD:227480	202/398 (51%)
		Ssl1	67..258	CDD:190848	98/190 (52%)
		C1_4	291..403	CDD:297864	60/111 (54%)
Gtf2h2	NP_001347635.1	Ssl1	64..255	CDD:367789	98/190 (52%)
Gtf2h2	NP_001347635.1	C1_4	289..389	CDD:352591	62/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837103
Domainoid	1	1.000	203	1.000	Domainoid score	I2965
eggNOG	1	0.900	-	-		E1_COG5151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1159
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1844
Isobase	1	0.950	-	0	Normalized mean entropy	S943
OMA	1	1.010	-	-		QHG54264
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004477
OrthoInspector	1	1.000	-	-		oto95069
orthoMCL	1	0.900	-	-		OOG6_102284
Panther	1	1.100	-	-	LDO	PTHR12695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1505
SonicParanoid	1	1.000	-	-		X3170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740