DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ssl1 and gtf-2H2C

DIOPT Version :9

Sequence 1:	NP_001262227.1	Gene:	Ssl1 / 40509	FlyBaseID:	FBgn0037202	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_499239.1	Gene:	gtf-2H2C / 176421	WormBaseID:	WBGene00011814	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	153/414 - (36%)
Similarity:	238/414 - (57%)	Gaps:	48/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADDEQEDQKEYRWETGYEKTW---EAIKDDEDGMLDGAIAEIIQKAKRQ-RQAQKSKQNRLGMM 61
            |.|||   ||.|.||.||.:..   :.:.:||.|.::.:||:.:..:||: |..::.::.|||:|
Worm     1 MDDDE---QKGYTWEAGYAEGLNINDVLVEDEGGSIEKSIAKYVADSKRKARLTKRPERIRLGIM 62

  Fly    62 RHMFVVLDCSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGT 126
            ||:.:|:|||..|:...:.|:|....:|.|:.|::.||:||||:|:|||..|.::|:::|.:||.
Worm    63 RHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGN 127

  Fly   127 SRVHLKALESLANVSLTSEPSLQNGLDLALKSLKVVPSHASREIVIIMGSLTTCDPVDINLTIDE 191
            .||..::|.:|.......:.||||.|.||..:||.:|.|.|||:|:::.:|:|.||.:|..||:.
Worm   128 IRVLKESLNTLTEAFCGGDFSLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIET 192

  Fly   192 LKKEGIRCSVISLSAEIHVARYLTQQTMGTFGAVLDDAHFRDQLMSQVDPPPAAKTQHNSLIRMG 256
            :|:..||||.|.||||:.|.:.:.:.|.|.:...||..|.:........||.:||:...:.|.:|
Worm   193 MKRMNIRCSAIGLSAEMFVCKEMAKATKGEYSVALDPDHLQLLFSKHTLPPSSAKSSECNAIHVG 257

  Fly   257 FPH-----TKNEVEGKDAPLSMCMCHIENLEEPSELTTTGHHCPQCNSKYCELPVECQSCGLTLV 316
            |||     |:          |.|:||    .:...:::.|..|.||.:::|.:|.||..|.||||
Worm   258 FPHHELITTR----------SFCVCH----PDTKPISSRGFICTQCGARHCSIPAECPVCKLTLV 308

  Fly   317 SAPHLARSYHHLFPVPNFEELPFEAMPASSSDLTSDVRECYGCAKAL-GQGVDKVADKVVFRCGF 380
            :||.|||::.||.|:..||::          ::|...  ||.|...| |:|         ||||.
Worm   309 AAPQLARAFRHLQPLSAFEQI----------EVTRGF--CYACETRLSGEG---------FRCGS 352

  Fly   381 CKQFFCVDCDIFIHDTLHACVGCN 404
            |:..||:|||..:|::||.|.|||
Worm   353 CQLVFCLDCDTLLHESLHVCPGCN 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssl1	NP_001262227.1	SSL1	10..407	CDD:227480	148/405 (37%)
		Ssl1	67..258	CDD:190848	73/190 (38%)
		C1_4	291..403	CDD:297864	44/112 (39%)
gtf-2H2C	NP_499239.1	SSL1	3..375	CDD:227480	149/409 (36%)
		Ssl1	68..259	CDD:190848	73/190 (38%)
		C1_4	283..375	CDD:297864	44/112 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159330
Domainoid	1	1.000	150	1.000	Domainoid score	I2709
eggNOG	1	0.900	-	-		E1_COG5151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1159
Inparanoid	1	1.050	281	1.000	Inparanoid score	I1751
Isobase	1	0.950	-	0	Normalized mean entropy	S943
OMA	1	1.010	-	-		QHG54264
OrthoDB	1	1.010	-	-		D285146at33208
OrthoFinder	1	1.000	-	-		FOG0004477
OrthoInspector	1	1.000	-	-		oto18021
orthoMCL	1	0.900	-	-		OOG6_102284
Panther	1	1.100	-	-	LDO	PTHR12695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1505
SonicParanoid	1	1.000	-	-		X3170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790