DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC4 and EMC4

DIOPT Version :9

Sequence 1:	NP_001303388.1	Gene:	EMC4 / 40505	FlyBaseID:	FBgn0037199	Length:	166	Species:	Drosophila melanogaster
Sequence 2:	NP_057538.1	Gene:	EMC4 / 51234	HGNCID:	28032	Length:	183	Species:	Homo sapiens

Alignment Length:	169	Identity:	87/169 - (51%)
Similarity:	112/169 - (66%)	Gaps:	13/169 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KKLKWALDFN------------GSKNADIPSPLGYNPSALVNQSEVVRDQRLVIKKSWDLALGPL 60
            ::.|||::.:            ||...|...|:||....:.:.|....|:.||.|:.||:|||||
Human    13 RRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPL 77

  Fly    61 KNIPMNLFIMYMSGNSISIFPIMMVGMMLIRPIKAIFTTQVTSKMAE-GAQGTGQRIVYFLGNLA 124
            |.||||||||||:||:|||||.|||.||..|||:|:.....|.||.| .:|...|.:||.:|||.
Human    78 KQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLM 142

  Fly   125 NVALALYKCQSMGLLPTHASDWLAFVQPQTRLEYYGGGI 163
            .:|||:|||||||||||||||||||::|..|:|:.|||:
Human   143 GLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGL 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC4	NP_001303388.1	DUF1077	43..152	CDD:283955	71/109 (65%)
EMC4	NP_057538.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39		6/30 (20%)
EMC4	NP_057538.1	DUF1077	56..170	CDD:399428	73/114 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145843
Domainoid	1	1.000	145	1.000	Domainoid score	I4606
eggNOG	1	0.900	-	-		E1_KOG3318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5879
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54843
OrthoDB	1	1.010	-	-		D1623701at2759
OrthoFinder	1	1.000	-	-		FOG0004297
OrthoInspector	1	1.000	-	-		oto89628
orthoMCL	1	0.900	-	-		OOG6_102320
Panther	1	1.100	-	-	LDO	PTHR19315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2002
SonicParanoid	1	1.000	-	-		X4099
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800