DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC4 and emc4

DIOPT Version :9

Sequence 1:	NP_001303388.1	Gene:	EMC4 / 40505	FlyBaseID:	FBgn0037199	Length:	166	Species:	Drosophila melanogaster
Sequence 2:	NP_991221.1	Gene:	emc4 / 402956	ZFINID:	ZDB-GENE-040426-1891	Length:	189	Species:	Danio rerio

Alignment Length:	167	Identity:	88/167 - (52%)
Similarity:	115/167 - (68%)	Gaps:	11/167 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KKLKWALDFN----------GSKNADIPSPLGYNPSALVNQSEVVRDQRLVIKKSWDLALGPLKN 62
            |::|||::.:          ..|:.|:..|:||:...:.:.|....|:.||.|:.||:||||||.
Zfish    21 KRMKWAVELSLGNSRSRSDRQGKDGDVMYPVGYSDKPVPDTSVQEADRNLVEKRCWDVALGPLKQ 85

  Fly    63 IPMNLFIMYMSGNSISIFPIMMVGMMLIRPIKAIFTTQVTSKMAE-GAQGTGQRIVYFLGNLANV 126
            |||||||||||||:|||||||||.||..|||:|:.:...|.|:.| .:|...|.:||.:|||...
Zfish    86 IPMNLFIMYMSGNTISIFPIMMVCMMAWRPIQALMSMSATFKLLESSSQQWLQGLVYLIGNLLGS 150

  Fly   127 ALALYKCQSMGLLPTHASDWLAFVQPQTRLEYYGGGI 163
            |||:||||||||||||:||||||::|..|||..|||:
Zfish   151 ALAIYKCQSMGLLPTHSSDWLAFIEPPQRLEIMGGGM 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC4	NP_001303388.1	DUF1077	43..152	CDD:283955	71/109 (65%)
emc4	NP_991221.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..63		5/32 (16%)
		DUF1077	62..176	CDD:283955	72/113 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579309
Domainoid	1	1.000	146	1.000	Domainoid score	I4510
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5879
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4101
OMA	1	1.010	-	-		QHG54843
OrthoDB	1	1.010	-	-		D1623701at2759
OrthoFinder	1	1.000	-	-		FOG0004297
OrthoInspector	1	1.000	-	-		oto41348
orthoMCL	1	0.900	-	-		OOG6_102320
Panther	1	1.100	-	-	LDO	PTHR19315
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2002
SonicParanoid	1	1.000	-	-		X4099
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940