DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and ATP2C2

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001273456.2	Gene:	ATP2C2 / 9914	HGNCID:	29103	Length:	975	Species:	Homo sapiens

Alignment Length:	1000	Identity:	528/1000 - (52%)
Similarity:	668/1000 - (66%)	Gaps:	98/1000 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KEPDEDNVDQQNG-NIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKI 142
            |:.:|..:|:|:. ..|:....:|   .|...|:......::|....||:.|||.......|...
Human    27 KDEEEALIDEQSELKAIEKEKKVT---ALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLA 88

  Fly   143 IGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEY 207
            .|.||.:....:|.||||::||:|||||||||||||||:.|:::|||||..|:|:||||||||||
Human    89 HGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEY 153

  Fly   208 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESS 272
            |||||||||.|||||||:|||||:|...|||||||||:|.|::|||:|||:||.|..||.:||||
Human   154 RSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESS 218

  Fly   273 FTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAE 337
            ||||.||..| ||..|  |...|.:.:.||.||||||:.|.|:|:|:.|||.|:|||||||||||
Human   219 FTGEAEPCSK-TDSPL--TGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAE 280

  Fly   338 EAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTV 402
            |.||||||||||.||.||:.:||.|||:|||:||.|||.|..||.|.||||||||||||||||.|
Human   281 ETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMV 345

  Fly   403 TLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYN 467
            ||.|||:||||:..||||||.||||||.:|:|||||||||.||||.|.::||||..|:|:|.||:
Human   346 TLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYD 410

  Fly   468 DQGEIHIRHCNNV--EMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAE 530
            .||.:.:.....|  |.:..::..|:|.|.|.|||.|:...::||||||||:|:|||..:.....
Human   411 GQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKN 475

  Fly   531 NYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAE 595
            :|:|.:|.|||||||.|||||..| ..::|:|:|.|||||.::..||.|..|...:|||.|..:.
Human   476 SYIRKKEIPFSSEQKWMAVKCSLK-TEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSF 539

  Fly   596 FLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQ 660
            .|.|...:|..||||||||.|..:..|.:.|||||.||||..|:|::::|.:|||.|||:||||.
Human   540 CLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDAL 604

  Fly   661 ETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTA 725
            ||||||                   ...:.||:...
Human   605 ETALAI-------------------GRNIGLCNGKL----------------------------- 621

  Fly   726 NLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGV 790
                      |.:||:|:|.:.:.:|......||||:|.||:|||:|:|:||.||.||.||||||
Human   622 ----------QAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGV 676

  Fly   791 NDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSI 855
            ||.||||.||||||||:.||||.||||:||||:|||..|:.|:||||||||||:|||||||||||
Human   677 NDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSI 741

  Fly   856 AALALIALATLMDIANPLNAMQILWINIIMDGPPAQ----------------------------- 891
            :||:||.|:|:.::.:||||||||||||||||||||
Human   742 SALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGESTWAGRA 806

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTM 956
            .|||||||.|..:|.||:|:..::::::::.:|:||:||:.|||::|.:||.:.. ..|.|.|||
Human   807 GLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDR-ASTPRTTTM 870

  Fly   957 TFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTP 1021
            |||||||||:||||:||||||.:|.||...|.|||.:|..||:||:.|:|.||||.|||||.|..
Human   871 TFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGA 935

  Fly  1022 YDIFFLVSLTSSVLVVSEIKKWFER 1046
            .|:.||..|.|||.::||:.|..|:
Human   936 LDLLFLTGLASSVFILSELLKLCEK 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	521/967 (54%)
		Cation_ATPase_N	112..179	CDD:279080	29/66 (44%)
		E1-E2_ATPase	191..425	CDD:278548	164/233 (70%)
		Cation_ATPase	496..579	CDD:289987	43/82 (52%)
		COG4087	<760..823	CDD:226572	47/62 (76%)
		Cation_ATPase_C	872..1044	CDD:279079	101/200 (51%)
ATP2C2	NP_001273456.2	ATPase-IIA2_Ca	55..960	CDD:130585	520/967 (54%)
		Cation_ATPase_N	63..125	CDD:279080	29/61 (48%)
		E1-E2_ATPase	149..368	CDD:278548	156/221 (71%)
		Cation_ATPase	441..523	CDD:289987	43/82 (52%)
		COG4087	<625..709	CDD:226572	54/83 (65%)
		Cation_ATPase_C	756..957	CDD:279079	100/201 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141100
Domainoid	1	1.000	234	1.000	Domainoid score	I2394
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1113	1.000	Inparanoid score	I228
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm41315
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770