Protein Alignment SPoCk and ATP2C2

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 1000
• Identity: 528/1000 - (52%)
• Similarity: 668/1000 - (66%)
• Gaps: 98/1000 - (9%)

  Fly    79 KEPDEDNVDQQNG-NIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKI 142
            |:.:|..:|:|:. ..|:....:|   .|...|:......::|....||:.|||.......|...
Human    27 KDEEEALIDEQSELKAIEKEKKVT---ALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLA 88

  Fly   143 IGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEY 207
            .|.||.:....:|.||||::||:|||||||||||||||:.|:::|||||..|:|:||||||||||
Human    89 HGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEY 153

  Fly   208 RSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESS 272
            |||||||||.|||||||:|||||:|...|||||||||:|.|::|||:|||:||.|..||.:||||
Human   154 RSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESS 218

  Fly   273 FTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAE 337
            ||||.||..| ||..|  |...|.:.:.||.||||||:.|.|:|:|:.|||.|:|||||||||||
Human   219 FTGEAEPCSK-TDSPL--TGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAE 280

  Fly   338 EAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTV 402
            |.||||||||||.||.||:.:||.|||:|||:||.|||.|..||.|.||||||||||||||||.|
Human   281 ETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMV 345

  Fly   403 TLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYN 467
            ||.|||:||||:..||||||.||||||.:|:|||||||||.||||.|.::||||..|:|:|.||:
Human   346 TLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYD 410

  Fly   468 DQGEIHIRHCNNV--EMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAE 530
            .||.:.:.....|  |.:..::..|:|.|.|.|||.|:...::||||||||:|:|||..:.....
Human   411 GQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKN 475

  Fly   531 NYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAE 595
            :|:|.:|.|||||||.|||||..| ..::|:|:|.|||||.::..||.|..|...:|||.|..:.
Human   476 SYIRKKEIPFSSEQKWMAVKCSLK-TEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSF 539

  Fly   596 FLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQ 660
            .|.|...:|..||||||||.|..:..|.:.|||||.||||..|:|::::|.:|||.|||:||||.
Human   540 CLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDAL 604

  Fly   661 ETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTA 725
            ||||||                   ...:.||:...
Human   605 ETALAI-------------------GRNIGLCNGKL----------------------------- 621

  Fly   726 NLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGV 790
                      |.:||:|:|.:.:.:|......||||:|.||:|||:|:|:||.||.||.||||||
Human   622 ----------QAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGV 676

  Fly   791 NDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSI 855
            ||.||||.||||||||:.||||.||||:||||:|||..|:.|:||||||||||:|||||||||||
Human   677 NDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSI 741

  Fly   856 AALALIALATLMDIANPLNAMQILWINIIMDGPPAQ----------------------------- 891
            :||:||.|:|:.::.:||||||||||||||||||||
Human   742 SALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGESTWAGRA 806

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTM 956
            .|||||||.|..:|.||:|:..::::::::.:|:||:||:.|||::|.:||.:.. ..|.|.|||
Human   807 GLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDR-ASTPRTTTM 870

  Fly   957 TFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTP 1021
            |||||||||:||||:||||||.:|.||...|.|||.:|..||:||:.|:|.||||.|||||.|..
Human   871 TFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGA 935

  Fly  1022 YDIFFLVSLTSSVLVVSEIKKWFER 1046
            .|:.||..|.|||.::||:.|..|:
Human   936 LDLLFLTGLASSVFILSELLKLCEK 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	512/933 (55%)
ATP2C2	NP_001273456.2	P-type_ATPase_SPCA	85..956	CDD:319779	512/933 (55%)