Protein Alignment SPoCk and Atp1a2

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_848492.1
• Gene: Atp1a2 / 98660
• MGIID: 88106
• Length: 1020
• Species: Mus musculus
• Alignment Length: 1058
• Identity: 307/1058 - (29%)
• Similarity: 480/1058 - (45%)
• Gaps: 212/1058 - (20%)

  Fly   115 SASEVAGRLQVDVRTGLKWTEAKYRAKII----GHNELLLVAEDPTWKKYIEQ-FRNPLILLLLG 174
            |..|:..:.|||:..||    ...||:.|    |.|.|......|.|.|:..| |....|||.:|
Mouse    45 SLDELGRKYQVDLSKGL----TNQRAQDILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIG 105

  Fly   175 SALVSV---IMKQFDDAVS-------ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCL 227
            :.|..:   |:...:|..|       |.:|.:::||  .::.||.:|.|.::..|.:||.:...:
Mouse   106 ALLCFLAYGILAAMEDEPSNDNLYLGIVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVI 170

  Fly   228 REGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTN 292
            |||......|.|:|.||:|.:..|||||||:|:..:....:|.||.|||:||..:..:.
Mouse   171 REGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEF------ 229

  Fly   293 VKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD----- 349
              .|.|   .:||.|..|....|..:|||::||:|:..|.:..:....|..:||:...::
Mouse   230 --THENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGQTPIAMEIEHFIQL 292

  Fly   350 ILGAQLSF-YSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAK 413
            |.|..:.. .||.::.:|:...||      |.....:.:.||.:||||...|||.|.|...|||:
Mouse   293 ITGVAVFLGVSFFVLSLILGYSWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAR 351

  Fly   414 RNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVT----GAGYNDQGEIH 473
            :|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|    ||.::.:
Mouse   352 KNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKR---- 412

  Fly   474 IRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG---------TLLGQPTEGALV-AVAMKNG-MYA 527
                      ....|.|..|..:||.|..:.|         ...|..:|.||: .:.:..| :..
Mouse   413 ----------SPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRK 467

  Fly   528 TAENYVRIQEYPFSSEQKMMAVKCIHKYNNN-KEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQ 591
            ..:...::.|.||:|..|...  .||:..:: :..:...|||.|.:|.:|:......:.:||.|:
Mouse   468 MRDRNPKVAEIPFNSTNKYQL--SIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKE 530

  Fly   592 NEAEFLAEAYEIGRKGLRVLA-----LAKGR--------------SMQDLIYCGLVGITDPPRPL 637
            .:..|.....|:|..|.|||.     |..|:              ..:.|.:.||:.:.||||..
Mouse   531 MQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAA 595

  Fly   638 VRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNC 702
            |.:::.....:|::|.|||||                   |.|.|...|.||.:.|..
Mouse   596 VPDAVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISEG------- 634

  Fly   703 LENAMKEIYLTALAQQGLPL--VTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYR 763
             ...:::|    .|:..:|:  |.........:|     |.::..|...|||::..:.:  ||.|
Mouse   635 -NETVEDI----AARLNIPVSQVNPREAKACVVH-----GSDLKDMTSEQLDEILRDHTEIVFAR 689

  Fly   764 VSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHT 828
            .||:.||.||:..||.|.||.:|||||||..||||||||||||.:|:||.|:||||||::|:|.:
Mouse   690 TSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFAS 754

  Fly   829 IIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSL 893
            |:..:|||:.||.|::..:.:.|:::|..:....|..:.:|..||..:.||.|::..|..||.||
Mouse   755 IVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISL 819

  Fly   894 GVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSAS------IIVLGTLWVFQREMADG------T 946
            ..|..:.|::|::|||.:    |..:|...|:|.:      |..||..:.:...:|:.      .
Mouse   820 AYEAAESDIMKRQPRNSQ----TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRL 880

  Fly   947 LG-------KTKRD--------------TTMTFTCFVFF-------DMFNALSCRSQTKSVFTIG 983
            ||       :|..|              ..:.|||...|       ...:.:.|:::..|||..|
Mouse   881 LGIRLDWDDRTTNDLEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQG 945

  Fly   984 LTTNRMFL--------LAVAFSI---IGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVV 1037
            : .|::.:        ||...|.   :|..|.:|  ||::.:...|. ||.:.        :.:.
Mouse   946 M-KNKILIFGLLEETALAAFLSYCPGMGVALRMY--PLKVTWWFCAF-PYSLL--------IFIY 998

  Fly  1038 SEIKK---------WFER 1046
            .|::|         |.|:
Mouse   999 DEVRKLILRRYPGGWVEK 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	297/1019 (29%)
Atp1a2	NP_848492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	307/1058 (29%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..231		8/26 (31%)