Protein Alignment SPoCk and PMC1

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_011509.1
• Gene: PMC1 / 852878
• SGDID: S000002974
• Length: 1173
• Species: Saccharomyces cerevisiae
• Alignment Length: 1169
• Identity: 291/1169 - (24%)
• Similarity: 493/1169 - (42%)
• Gaps: 279/1169 - (23%)

  Fly    82 DEDNVDQQNGNIIQTGLTLTPEMLLSTSE-SSTHSASEVAG--------------RLQVDVRTGL 131
            :|:|.....||  :.|  :.....||.|: |..|:...:..              .|:.|...|:
Yeast    14 NENNKPSYTGN--ENG--VYDNFKLSKSQLSDLHNPKSIRSFVRLFGYESNSLFKYLKTDKNAGI 74

  Fly   132 KWTE-AKYRA----KIIGHNELLLVAEDPTWKKYIE----QFRNPLILLLLGSALVSVIM----- 182
            ...| :.||.    |..|.|.|    .:...|.:::    .|.:..:.||..:|:||.::
Yeast    75 SLPEISNYRKTNRYKNYGDNSL----PERIPKSFLQLVWAAFNDKTMQLLTVAAVVSFVLGLYEL 135

  Fly   183 --------------KQFD--DAVSITIAILIVVTVAFIQEYRSEKSLEEL-KKLVPPECHCLREG 230
                          ||.|  :.|:|.||:.:||.|:...:|:.|....:| ||....:...:|..
Yeast   136 WMQPPQYDPEGNKIKQVDWIEGVAIMIAVFVVVLVSAANDYQKELQFAKLNKKKENRKIIVIRND 200

  Fly   231 RLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARK--ITDVL-----L 288
            :........::.||::.|..||.||||..:... ....||||.|||:...:|  :.:.|     .
Yeast   201 QEILISIHHVLVGDVISLQTGDVVPADCVMISG-KCEADESSITGESNTIQKFPVDNSLRDFKKF 264

  Fly   289 NNTNVKDHSNMKNIA--------------FMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEA 339
            |:.:..:||...:|.              ..|:.:..|.|:|::.|.|..|.:|:....:.| |.
Yeast   265 NSIDSHNHSKPLDIGDVNEDGNKIADCMLISGSRILSGLGRGVITSVGINSVYGQTMTSLNA-EP 328

  Fly   340 PKTPLQKSMDILGAQLSFY---SFLIIGVIMLLGWL-----------------QGKPLSEMFNIS 384
            ..||||..:..|...:|.|   |.:|:.:::...:|                 :|.....:|..|
Yeast   329 ESTPLQLHLSQLADNISVYGCVSAIILFLVLFTRYLFYIIPEDGRFHDLDPAQKGSKFMNIFITS 393

  Fly   385 VSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT 449
            :::.|.|:|||||:.||:.||....||.|..::|:.|.:.||:|....:|||||||||:|.||..
Yeast   394 ITVIVVAVPEGLPLAVTLALAFATTRMTKDGNLVRVLRSCETMGSATAVCSDKTGTLTENVMTVV 458

  Fly   450 IIITSDGYMADVTGAGYNDQGEIHIR-----HCN---------NVEMAKT--------------- 485
            .....:....|......::|.:::.:     :|:         |:.:..|
Yeast   459 RGFPGNSKFDDSKSLPVSEQRKLNSKKVFEENCSSSLRNDLLANIVLNSTAFENRDYKKNDKNTN 523

  Fly   486 ---NITNLLEIGAVCNN--AYIQNGT-------------------LLGQPTEGALVAVA-MKNGM 525
               |::..|.....|.:  ::.:.|.                   .:|..||.||:::| :..|:
Yeast   524 GSKNMSKNLSFLDKCKSRLSFFKKGNREDDEDQLFKNVNKGRQEPFIGSKTETALLSLARLSLGL 588

  Fly   526 YATAENYVR------------IQEYPFSSEQKMMAVKCIHKYNNNKEEI--FFAKGALETLLPQC 576
            ......|:|            :|..||.|.:|...:...:|...||:..  ||.|||.|.:...|
Yeast   589 QPGELQYLRDQPMEKFNIEKVVQTIPFESSRKWAGLVVKYKEGKNKKPFYRFFIKGAAEIVSKNC 653

  Fly   577 TKYQFGTQTV-PLTKQNEAEFLAEAYEIGRKGLRVLALAKG------------------------ 616
            :..:....|: .:.:.|:.|...|...:....||.:::|..
Yeast   654 SYKRNSDDTLEEINEDNKKETDDEIKNLASDALRAISVAHKDFCECDSWPPEQLRDKDSPNIAAL 718

  Fly   617 ----RSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPT 677
                .|.:.||..||:||.||.|..||||::...::||.|:|||||...||.||
Yeast   719 DLLFNSQKGLILDGLLGIQDPLRAGVRESVQQCQRAGVTVRMVTGDNILTAKAI----------- 772

  Fly   678 HAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQE 742
                                 :.||      .|..|.::.:.               :..:.|.|
Yeast   773 ---------------------ARNC------AILSTDISSEA---------------YSAMEGTE 795

  Fly   743 MDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGK 807
            ..::.:::..::..|:.|..|.||..|..:|::|:..|::|.:||||.||..|||.||:|.:||.
Yeast   796 FRKLTKNERIRILPNLRVLARSSPEDKRLLVETLKGMGDVVAVTGDGTNDAPALKLADVGFSMGI 860

  Fly   808 NGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATL--MDIA 870
            :||:|.:||:|:||:.|||..|:.||:.|:.:..:|:.|::|||..:|.|:.|..::::  .|..
Yeast   861 SGTEVAREASDIILMTDDFSAIVNAIKWGRCVSVSIKKFIQFQLIVNITAVILTFVSSVASSDET 925

  Fly   871 NPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTL 935
            :.|.|:|:||||:|||...|.:|..:..|.:::.:|||.....:|:.|....:|..|::.::.|.
Yeast   926 SVLTAVQLLWINLIMDTLAALALATDKPDPNIMDRKPRGRSTSLISVSTWKMILSQATLQLIVTF 990

  Fly   936 WV--------FQREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCR---------------SQTK 977
            .:        |::...:.|..:.::...|||..||:...|..|..|               |...
Yeast   991 ILHFYGPELFFKKHEDEITSHQQQQLNAMTFNTFVWLQFFTMLVSRKLDEGDGISNWRGRISAAN 1055

  Fly   978 SVFTIGLTTNRMFLLAVAFSIIG--QMLVVYF--PPLQMVFQTEALTPYDIFF-LVSLTSSVLV 1036
            ..|...|..|..||..:|  |||  |:|:::|  .|..:..||:::....:.. ::||...|||
Yeast  1056 LNFFQDLGRNYYFLTIMA--IIGSCQVLIMFFGGAPFSIARQTKSMWITAVLCGMLSLIMGVLV 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	276/1096 (25%)
PMC1	NP_011509.1	ATPase-IIB_Ca	15..1123	CDD:273668	291/1168 (25%)