DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and ENA1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_010325.1	Gene:	ENA1 / 851610	SGDID:	S000002447	Length:	1091	Species:	Saccharomyces cerevisiae

Alignment Length:	1067	Identity:	281/1067 - (26%)
Similarity:	468/1067 - (43%)	Gaps:	246/1067 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 THSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKY----IEQFRNPLILLLL 173
            |.:|.|.|..:...:..||...|..:|.|.:|.|.|    .|.|...|    :.|..|.:|::||
Yeast    19 TLTAEEAAEFIGTSLTEGLTQDEFVHRLKTVGENTL----GDDTKIDYKAMVLHQVCNAMIMVLL 79

  Fly   174 GSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLAR 238
            .|.::|..|..:.....|:..|.:.|.:..:|||::.|::..||.|..|..|.:|.|:.:|..::
Yeast    80 ISMIISFAMHDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVIRNGKSETINSK 144

  Fly   239 ELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIA 303
            ::|||||..:.|||.:|||:||.|..:...|||..|||:.|..|..:::..........:..|:|
Yeast   145 DVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEEETSVGDRLNLA 209

  Fly   304 FMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEA-----PK---------------------- 341
            |..:.|..|..||||:.|...||.|::.|.:|.:..     |.
Yeast   210 FSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWISTKKVTGAFLGTN 274

  Fly   342 --TPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNI-------SVSLAVAAIPEGLP 397
              |||.:.:..| |.|.|:..::..:|::        .|:.|::       ::.:|::.||..|.
Yeast   275 VGTPLHRKLSKL-AVLLFWIAVLFAIIVM--------ASQKFDVDKRVAIYAICVALSMIPSSLV 330

  Fly   398 IVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEM-----------TATII 451
            :|:|:|:::|...|..||.||:||.::|.||.||.||||||||||:.:|           |.||.
Yeast   331 VVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWIPRFGTITIS 395

  Fly   452 ITSDGYMADVTGA-----------GYNDQGEIHIRH-----------CNNVEM----------AK 484
            .:.|.:..:....           .:|:.|::.|..           ..:::|          ..
Yeast   396 NSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPEDIDMDLFQKWLETATL 460

  Fly   485 TNITNLLEIGAV-CNNAYIQNGTLLGQPTEGALVAVAMKNGMYATA-----------EN------ 531
            .||..:.:..|. |..|:       |.|||.|:...|.|..:...|           ||
Yeast   461 ANIATVFKDDATDCWKAH-------GDPTEIAIQVFATKMDLPHNALTGEKSTNQSNENDQSSLS 518

  Fly   532 ----------YVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIF--FAKGALETLLPQCTKY--QFG 582
                      :..|.|:||.|..|.|:    ..|.||..|.:  :.|||.|:::..|:.:  :.|
Yeast   519 QHNEKPGSAQFEHIAEFPFDSTVKRMS----SVYYNNHNETYNIYGKGAFESIISCCSSWYGKDG 579

  Fly   583 TQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA--------------------KGRSMQDLIYCGL 627
            .:..|||..:........|.:..:|||||..|                    :..:..||::.||
Yeast   580 VKITPLTDCDVETIRKNVYSLSNEGLRVLGFASKSFTKDQVNDDQLKNITSNRATAESDLVFLGL 644

  Fly   628 VGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLC 692
            :||.||||.....:::...|:|:.|.|:|||...||.||  ::.:..:||:
Yeast   645 IGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAI--AQEVGILPTN-------------- 693

  Fly   693 SASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANN 757
                      |.:..:||                   :|::   .::|.:.|.::|.::|.:...
Yeast   694 ----------LYHYSQEI-------------------VDSM---VMTGSQFDGLSEEEVDDLPVL 726

  Fly   758 VSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILV 822
            ..|..|.||:.|:.::::|.|......||||||||..:||.|::|||||.||:||.|||:|::|.
Yeast   727 PLVIARCSPQTKVRMIEALHRRKKFCTMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLS 791

  Fly   823 NDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIAN-----PLNAMQILWIN 882
            :|:|.:|:.|:|||:.:..||:.||...|:.::|....:.:..:....|     ||:.:::|||.
Yeast   792 DDNFASILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWII 856

  Fly   883 IIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVN-----VLLSASIIV--LGTLWVFQR 940
            ::....||..||:|....|::.:.|.:.:..:.|..|:::     ::::.|.:.  .|:|:....
Yeast   857 VVTSCFPAMGLGLEKAAPDLMDRPPHDSEVGIFTWEVIIDTFAYGIIMTGSCMASFTGSLYGINS 921

  Fly   941 ----EMADGTLGKTKRD---------TTMTFTCFV-----------FFDMFNALSCRSQTKSVFT 981
                ...|||...:.||         .|||:...:           ||.|..  ...|..|..|.
Yeast   922 GRLGHDCDGTYNSSCRDVYRSRSAAFATMTWCALILAWEVVDMRRSFFRMHP--DTDSPVKEFFR 984

  Fly   982 IGLTTNRMFLLAVAFSIIGQMLVVYFP 1008
             .:..|:....::.|..:....|||.|
Yeast   985 -SIWGNQFLFWSIIFGFVSAFPVVYIP 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	281/1067 (26%)
		Cation_ATPase_N	112..179	CDD:279080	21/69 (30%)
		E1-E2_ATPase	191..425	CDD:278548	78/269 (29%)
		Cation_ATPase	496..579	CDD:289987	28/112 (25%)
		COG4087	<760..823	CDD:226572	32/62 (52%)
		Cation_ATPase_C	872..1044	CDD:279079	37/168 (22%)
ENA1	NP_010325.1	ATPase-IID_K-Na	11..1055	CDD:130586	281/1067 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S507
OMA	1	1.010	-	-		QHG53587
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.730