DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp13a2

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006539299.1	Gene:	Atp13a2 / 74772	MGIID:	1922022	Length:	1252	Species:	Mus musculus

Alignment Length:	1017	Identity:	232/1017 - (22%)
Similarity:	384/1017 - (37%)	Gaps:	253/1017 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GRLQVDVR---TGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIM 182
            ||...||.   :||...:...|..|.|.|.:.:..     |.|::...:..:....|....|:.:
Mouse   269 GRTCDDVHCSSSGLSLQDQATRKTIYGPNVISIPV-----KSYLQLLADEALNPYYGFQAFSIAL 328

  Fly   183 KQFDD----AVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPG 243
            ...|.    |:.|.:...|.:.:|..:..:...:|.::.||......|...|..:...:.|||||
Mouse   329 WLADHYYWYALCIFLISAISICLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPG 393

  Fly   244 DIVHL-NVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKD-------HSNMK 300
            |.:.| ..|..:|.|..|. |.:..::|||.|||:.|..|        |.:.:       .::.:
Mouse   394 DCLVLPQEGGVMPCDAALV-AGECVVNESSLTGESTPVLK--------TALPEGPKPYCPETHRR 449

  Fly   301 NIAFMGTLV---RCGNGK---GIVVSTGE-RSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFY 358
            :..|.|||:   |...|.   .:|..||. .::.|.|..::..........:.||..:.| ||..
Mouse   450 HTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAA-LSVL 513

  Fly   359 SFL--IIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKL 421
            :.|  :..:|:|  :....|:.|:...::.|....:|..||..:||.......|:..:.......
Mouse   514 ALLGTVYSIIIL--YRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHP 576

  Fly   422 PTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHI----RHCNNVEM 482
            ..:...|.:.::|.|||||||:           ||  .||.|. ...:|::.:    ..|:
Mouse   577 LRINLGGKLRLVCFDKTGTLTE-----------DG--LDVMGV-VPLKGQVLLPLVPEPCH---- 623

  Fly   483 AKTNITNLLEIGAVCNNAYIQNGTLLGQPTE---------------------GALVAVAMK---N 523
              ..:..||...|.|:.....:.|.:|.|.:                     |:.|.|.|:   .
Mouse   624 --LPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEGPAAGSAPGSQVLVVMRPPPG 686

  Fly   524 GMYATAENYVRIQ---EYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQT 585
            |.....|..|.:.   .:||||..:.|.|  :..:....:...:.||:.|.:...|:     .:|
Mouse   687 GPRQQEEPPVPVSVLCRFPFSSALQRMDV--VVTWPGATQPEAYVKGSPELVASLCS-----PET 744

  Fly   586 VPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSM------------------QDLIYCGLVGITD 632
            ||      ::|..........|.||:||| |:.:                  ::|...||:.:.:
Mouse   745 VP------SDFSQVLQSYTAAGYRVVALA-GKPLPIAPSLAAAQQLTRDTVERELSLLGLLVMRN 802

  Fly   633 PPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASAC 697
            ..:|.....|:.|.::|:|..|||||..:||:.:                           |.||
Mouse   803 LLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTV---------------------------ARAC 840

  Fly   698 CSTNCLENAMKEIYLTALAQQGLPLVT-------------ANLIGIDTIH-----HQTLSGQEMD 744
            ......|: :..|:.|. .:||.|...             |...|..|:.     |..|||....
Mouse   841 GMVGAQEH-LAVIHATH-PEQGQPAALEFLPTESSAVMNGAKATGYPTVPEPQSCHLALSGSTFA 903

  Fly   745 QMNEH---QLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMG 806
            .:.:|   .|.||....:||.|::|..|.|:|..|||....|||.|||.||..|||.||:||::.
Mouse   904 VLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLS 968

  Fly   807 KNGTDVCKEAADMILVNDDFHTIIAAIE-------EGK-------GIF-----YNIRNFVR---- 848
            :      .||:    |...|.:.:|:||       ||:       .:|     |::..|:.
Mouse   969 Q------AEAS----VVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLIL 1023

  Fly   849 FQLSTSIAALALIAL--------ATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQ 905
            :.::|::..|..:|:        |.||....|.       :.::...||...|.| ||...:|.|
Mouse  1024 YTINTNLGDLQFLAIDLVITTTVAVLMSRTGPA-------LTLVRARPPGALLSV-PVLGSLLLQ 1080

  Fly   906 KPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKT--------KRDTTMTFTCFV 962
                       .::|..:.|....:|:...|..       .|.:|        ..:.|:.|:...
Mouse  1081 -----------VALVAGIQLGGYFLVIAQPWFV-------PLNRTVPAPDNLPNYENTVVFSLSG 1127

  Fly   963 FFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLV 1004
            |  .:..|:......:.|...|.||..||:|:|  ::|.:||
Mouse  1128 F--QYLILAAAVSKGAPFRQPLYTNVPFLVALA--LLGSVLV 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	232/1017 (23%)
		Cation_ATPase_N	112..179	CDD:279080	13/60 (22%)
		E1-E2_ATPase	191..425	CDD:278548	57/250 (23%)
		Cation_ATPase	496..579	CDD:289987	21/109 (19%)
		COG4087	<760..823	CDD:226572	27/62 (44%)
		Cation_ATPase_C	872..1044	CDD:279079	30/141 (21%)
Atp13a2	XP_006539299.1	P-ATPase-V	35..1195	CDD:273738	232/1017 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840