Protein Alignment SPoCk and atp1a1a.3

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_571763.1
• Gene: atp1a1a.3 / 64614
• ZFINID: ZDB-GENE-001212-3
• Length: 1024
• Species: Danio rerio
• Alignment Length: 1103
• Identity: 309/1103 - (28%)
• Similarity: 491/1103 - (44%)
• Gaps: 220/1103 - (19%)

  Fly    68 KPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTH--SASEVAGRLQVDVRTG 130
            |.||    |:.|:.||                     |....|...|  :..|::.:...|:..|
Zfish    24 KKGK----KNKKDMDE---------------------LKKEVEMDDHKLTLEELSRKYGTDLNKG 63

  Fly   131 LKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSAL------VSVIMKQ--FD 186
            |..|.||......|.|.|......|.|.|:..| |.....||.:|:.|      :....::  .:
Zfish    64 LSITRAKEILARDGPNALTPPVTTPEWVKFCRQLFGGFQTLLWIGALLCFFAYSIQAASEEEPAN 128

  Fly   187 DAVSITIAILIVVTV----AFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVH 247
            |.:.:.:.:..||||    ::.||.:|.:.::..:.|||.:...:|||......|.::|.||:|.
Zfish   129 DNLYLGLVLAFVVTVNGCFSYYQEAKSSRIMDSFRNLVPQKALVVREGEKSVIDAEDVVVGDLVE 193

  Fly   248 LNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCG 312
            :..|||:|||:|:..:....:|.||.|||:||..:..::..:|.     ...:||||..|....|
Zfish   194 VKGGDRIPADIRIVSSQGCKVDNSSLTGESEPQTRAPEMSSDNP-----LETRNIAFFSTNCVDG 253

  Fly   313 NGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD-----ILGAQLSF-YSFLIIGVIMLLGW 371
            ..:|:||:||:|:..|.:..:..:.|..:||:.:.::     |.|..:.. .:||::.:|:...|
Zfish   254 AARGVVVNTGDRTVMGRIASLASSLEGGQTPIAREIEHFIHIITGVAVFLGLTFLVLSLILGYNW 318

  Fly   372 LQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSD 436
            |:|    .:|.|.:  .||.:|||||..|||.|.|...||||:|.:||.|..|||||....||||
Zfish   319 LEG----VIFLIGI--IVANVPEGLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSD 377

  Fly   437 KTGTLTKNEMT-ATIIITSDGYMADV----TGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAV 496
            ||||||:|.|| |.:...:..::||.    |||.:              :.:....:.|..:..:
Zfish   378 KTGTLTQNRMTVAHMWFDNHIHIADTTENQTGASF--------------DRSSATWSALARVAGL 428

  Fly   497 CNNAYIQNG---------TLLGQPTEGALV-AVAMKNGMYA-TAENYVRIQEYPFSSEQKMMAVK 550
            ||.|..|:.         ...|..:|.||: .:.:..|..| ..|||.::.|.||:|..|...
Zfish   429 CNRAVFQSNQSHIPVLKRDTAGDASESALLKCIELSCGSVAEMRENYTKLAEIPFNSTNKYQV-- 491

  Fly   551 CIHKYNNNKE--EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLAL 613
            .|||..|:.|  .:...|||.|.:|.:|:......:..|:..:.:..|.....|:|..|.|||..
Zfish   492 SIHKNPNSSEPKHLLVMKGAPERILERCSTIFIQGKEQPMDDEMKDAFQNAYLELGGLGERVLGF 556

  Fly   614 A----------KGRSM---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDA 659
            .          :|.:.         ::|.:.||:.:.||||..|.:::.....:|::|.|||||
Zfish   557 CHFCLPDDQFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGD- 620

  Fly   660 QETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVT 724
                              |.|.|...|.||.:.|.                     ..:.:..:.
Zfish   621 ------------------HPITAKAIAKGVGIISE---------------------GNETVDDIA 646

  Fly   725 ANL-IGIDTIHHQ-----TLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGN 781
            |.| |.||.::.:     .:.|.|:..|.:.|||.|..:.:  ||.|.||:.||.||:..||.|.
Zfish   647 ARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQHHTEIVFARTSPQQKLIIVEGCQRQGA 711

  Fly   782 IVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNF 846
            ||.:|||||||..||||||||:|||..|:||.|:||||||::|:|.:|:..:|||:.||.|::..
Zfish   712 IVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS 776

  Fly   847 VRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVK 911
            :.:.|::.|..::...:..|:.|..||..:.||.|::..|..||.||..|..:.|::|::|||.
Zfish   777 IAYTLTSKIPEMSPFLMFVLVGIPLPLGTVTILCIDLGTDMVPAISLAYETAESDIMKRQPRNA- 840

  Fly   912 QPMITKSVVVNVLLSAS----------------IIVL---------------------------- 932
               .|..:|...|:|.|                .::|
Zfish   841 ---ATDRLVNERLISVSYGQIGMIQAVGGFFTYFVILAENGFLPYDLVGIRVGWEDRFLNDLEDS 902

  Fly   933 -GTLWVFQ-REMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVA 995
             |..|.:: |::.:.|.      .|..|...|.....:.|.|:::..|:|..|: .||:....:.
Zfish   903 YGQQWTYESRKIVEYTC------HTAFFASIVIVQWTDLLICKTRRLSIFQQGM-KNRVLTFGLL 960

  Fly   996 FSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFERT-----MERKMY 1053
            ........:.|.|.:::..:...|.|...|.....:..:.:..|::|:..|.     :||:.|
Zfish   961 EETALAAFLSYCPGMEVAVRMYPLKPLWWFCAFPYSLLIFIYDEVRKYILRRNPGGWVERETY 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	298/1055 (28%)
		Cation_ATPase_N	112..179	CDD:279080	20/75 (27%)
		E1-E2_ATPase	191..425	CDD:278548	80/243 (33%)
		Cation_ATPase	496..579	CDD:289987	29/95 (31%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	43/217 (20%)
atp1a1a.3	NP_571763.1	ATPase-IIC_X-K	32..1024	CDD:273445	304/1091 (28%)
		Cation_ATPase_N	41..115	CDD:214842	21/73 (29%)
		E1-E2_ATPase	135..366	CDD:278548	80/241 (33%)
		Cation_ATPase	428..522	CDD:289987	29/95 (31%)
		COG4087	604..753	CDD:226572	68/188 (36%)
		Cation_ATPase_C	800..1009	CDD:279079	43/219 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920