Protein Alignment SPoCk and atp1a3a

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_571759.2
• Gene: atp1a3a / 64610
• ZFINID: ZDB-GENE-001212-7
• Length: 1023
• Species: Danio rerio
• Alignment Length: 1100
• Identity: 312/1100 - (28%)
• Similarity: 493/1100 - (44%)
• Gaps: 210/1100 - (19%)

  Fly    59 DSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGRL 123
            |.:..|:..|.||  |:.|.|:.                :.||...:         |..||..:.
Zfish    18 DDKESPKKGKGGK--DLDDLKKE----------------VPLTEHKM---------SIEEVCRKY 55

  Fly   124 QVDVRTGL-KWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSA---LVSVIMK 183
            ..|:..|| ....|:|.|: .|.|.|......|.|.|:..| |....|||.:|:.   |...|..
Zfish    56 NTDIVQGLTNARAAEYLAR-DGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYAIQA 119

  Fly   184 QFDDA-------VSITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARE 239
            ..:|.       :.|.::.::::|  .::.||.:|.|.:|..|.:||.:...:|||......|.|
Zfish   120 ATEDEPAGDNLYLGIVLSAVVIITGCFSYFQEAKSSKIMESFKNMVPQQALVIREGEKLQINAEE 184

  Fly   240 LVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSN---MKN 301
            :|.||:|.:..|||:|||:|:..|....:|.||.|||:||..:..|.        .|.|   .:|
Zfish   185 VVGGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDC--------THDNPLETRN 241

  Fly   302 IAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD-----ILGAQLSF-YSF 360
            |||..|....|..:||||.||:|:..|.:..:....|..|||:.|.::     |.|..:.. .:|
Zfish   242 IAFFSTNCVEGTARGIVVCTGDRTVMGRIATLTSGLETGKTPIAKEIEHFIHIITGVAVFLGVTF 306

  Fly   361 LIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVE 425
            .|:.:|:...||      |.....:.:.||.:||||...|||.|.|...|||::|.:||.|..||
Zfish   307 FILSIILGYSWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVE 365

  Fly   426 TLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITN 489
            |||..:.||||||||||:|.|| |.:...:..:.||.|    .||........:...:|
Zfish   366 TLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT----EDQSGASFDKSSGTWLA------ 420

  Fly   490 LLEIGAVCNNAYIQNG---------TLLGQPTEGALV-AVAMKNG-MYATAENYVRIQEYPFSSE 543
            |..:.|:||.|..:.|         .:.|..:|.||: .:.:..| :.|..:...::.|.||:|.
Zfish   421 LARVAALCNRAVFKAGQESLPILKRDVAGDASESALLKCIELSCGSVKAMRDKNKKVAEIPFNST 485

  Fly   544 QKMMAVKCIHKYNNNKEE--IFFAKGALETLLPQC-TKYQFGTQTVPLTKQNEAEFLAEAYEIGR 605
            .|...  .:|:.:.::|.  :...|||.|.:|.:| |..|.|.:. |:.::.:..|.....|:|.
Zfish   486 NKYQL--SVHELDESEENHYLLVMKGAPERILDRCSTILQQGKEQ-PMDEELKEAFQNAYLELGG 547

  Fly   606 KGLRVLALA----------KGRSM---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVR 651
            .|.|||...          ||.:.         .:|.:.||:.:.||||..|.:::.....:|::
Zfish   548 LGERVLGFCHLVMPGDKYPKGFAFDTDDINFQTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIK 612

  Fly   652 VKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALA 716
            |.|||||                   |.|.|...|.||.:.|..        ...:::|    .|
Zfish   613 VIMVTGD-------------------HPITAKAIAKGVGIISEG--------NETVEDI----AA 646

  Fly   717 QQGLPLVTANLIGID--TIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQ 777
            :..:|:...|.....  .||     |.::..:::.|:|:|..|.:  ||.|.||:.||.||:..|
Zfish   647 RLNIPVSQVNPRDAKACVIH-----GTDLKDLSQDQMDEVLKNHTEIVFARTSPQQKLIIVEGCQ 706

  Fly   778 RSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYN 842
            |.|.||.:|||||||..||||||||:|||.:|:||.|:||||||::|:|.:|:..:|||:.||.|
Zfish   707 RQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 771

  Fly   843 IRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKP 907
            ::..:.:.|:::|..:.......|::|..||..:.||.|::..|..||.||..|..:.|::|::|
Zfish   772 LKKSIAYTLTSNIPEITPFLFFILVNIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQP 836

  Fly   908 RNVKQPMITKSVVVNV------LLSA------------------SIIV----------------- 931
            ||..:..:....::::      ::.|                  |::|
Zfish   837 RNPLRDKLVNERLISIAYGQIGMIQALGGFFSYFVILAENGFLPSVLVGIRLNWDDRSNNDLEDS 901

  Fly   932 LGTLWVF-QREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVA 995
            .|..|.: ||::.:.|.      .|..|...|.....:.:.|:::..|||..|: .|::.:..:.
Zfish   902 YGQQWTYEQRKIVEFTC------HTAFFVSIVVVQWADVIICKTRRNSVFQQGM-KNKILIFGLF 959

  Fly   996 FSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---------WFER 1046
            ........:.|.|.:.:..:...|.|...|.....:..:.|..||:|         |.|:
Zfish   960 EETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEK 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	302/1048 (29%)
		Cation_ATPase_N	112..179	CDD:279080	22/71 (31%)
		E1-E2_ATPase	191..425	CDD:278548	83/244 (34%)
		Cation_ATPase	496..579	CDD:289987	24/96 (25%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	42/222 (19%)
atp1a3a	NP_571759.2	ATPase-IIC_X-K	30..1023	CDD:273445	308/1087 (28%)
		Cation_ATPase_N	41..114	CDD:214842	23/82 (28%)
		E1-E2_ATPase	134..365	CDD:278548	83/244 (34%)
		Cation_ATPase	427..521	CDD:289987	23/95 (24%)
		COG4087	606..752	CDD:226572	67/181 (37%)
		Cation_ATPase_C	799..1008	CDD:279079	42/215 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850