DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and JYalpha

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster

Alignment Length:	1041	Identity:	313/1041 - (30%)
Similarity:	487/1041 - (46%)	Gaps:	220/1041 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ESSTHS--ASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIE-QFRNPLILL 171
            |:..|.  ..|:..||:.|...||.:.|||.|.:|.|.|.|......|.|..::: .|....|||
  Fly    29 ETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPTPKWIVFLKTMFGGFAILL 93

  Fly   172 LLGSALVSV-----IMKQF---DDAVSITIAILIVVTV----AFIQEYRSEKSLEELKKLVPPEC 224
            ..||.|..|     :..|.   ||.:.:.||:.::|.|    .:.|.::|...::..|.|||...
  Fly    94 WAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQVHKSSSIMDSFKNLVPQYA 158

  Fly   225 HCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLN 289
            ..:|||.::|..:.|:|.||||.:..|||||||:|:.||..|.:|.||.|||:||..:.|:.
  Fly   159 TVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVDNSSLTGESEPQVRSTEF--- 220

  Fly   290 NTNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD-- 349
                 .|.|   .||:||..|.|..|..:|:|::||:.:..|.:..:....:..::|:.:.:.
  Fly   221 -----THENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPISREIQLF 280

  Fly   350 ---------ILGAQLSFYSF-LIIG------VIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPI 398
                     |||  |||::. |.:|      |:.|:|                :.||.:||||.:
  Fly   281 IRFITIFAIILG--LSFFAISLTLGYEFIDAVVFLIG----------------IIVANVPEGLLV 327

  Fly   399 VVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT------IIITSDGY 457
            .|||.|.|...|||.:|.:||.|..|||||..:.||||||||||:|.||..      ||:.||
  Fly   328 TVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESD-- 390

  Fly   458 MADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG---------TLLGQPTE 513
                |...:..         ::.::...:...|....|:||:|..:.|         .:.|..:|
  Fly   391 ----TTESFRG---------SHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASE 442

  Fly   514 GALV--AVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFF---AKGALETLL 573
            .||:  ...:..|:.|..:.::::.|.||:|.:|...  .:|::|::  :.:|   .|||.|.:|
  Fly   443 AALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQV--SVHEFNSS--DGYFIVEMKGAPERIL 503

  Fly   574 PQCTKYQFGTQTVPLTKQNEAEFLAEAY-EIGRKGLRVLALA-------------------KGRS 618
            .:|:.......:|.||...:.|| .||| |:|..|.|||..|                   ....
  Fly   504 DRCSTIIIQGLSVELTPTLKLEF-EEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFP 567

  Fly   619 MQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAW 683
            :::|.:.||:.:.||||..|.:::.....:||||.|||||...||.||  :|.:..:.|
  Fly   568 LENLRFLGLISLIDPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAI--ARSVGIITT------ 624

  Fly   684 PTAGGVPLCSASACCSTNCLENAMKEIYLTAL---AQQGLPLVTANLIGIDTIHHQTLSGQEMDQ 745
            |||                 |:..|:..:|.|   ::|...:|         :|     |.|:.:
  Fly   625 PTA-----------------EDIAKQRGVTVLDIDSRQATAIV---------VH-----GGELRE 658

  Fly   746 MNEHQLDKVA--NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKN 808
            |...:||.|.  :|..||.|.||:.||.||::.||.|.||.:|||||||..|||:||||:|||.:
  Fly   659 MKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGIS 723

  Fly   809 GTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPL 873
            |:||.|:||||||::|:|.:|:..||||:.||.|::..:.:.|::::..:.......:.||...|
  Fly   724 GSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLAL 788

  Fly   874 NAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRN-VKQPMITKSVVVNVLLSASIIV------ 931
            ..:.||.|:|..|..||.||..|..:.|::.:.||: .:..::.|.:::...|...:|.
  Fly   789 GTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVACFF 853

  Fly   932 ----------------------------------LGTLWVF-QREMADGTLGKTKRDTTMTFTCF 961
                                              .|..|.: :|::.:.|.|      |..|...
  Fly   854 TFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAG------TGFFVSI 912

  Fly   962 VFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFF 1026
            |...:|:.|.|:::..|:...|: .|.:...|:....|...|:.|.|    ||: :.|..|.|.|
  Fly   913 VVTQVFDLLICKTRRNSILQQGM-GNHVLNFALVLEFIIACLLCYVP----VFE-KTLRMYSIKF 971

  Fly  1027 L 1027
            :
  Fly   972 I 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	313/1041 (30%)
		Cation_ATPase_N	112..179	CDD:279080	24/69 (35%)
		E1-E2_ATPase	191..425	CDD:278548	84/258 (33%)
		Cation_ATPase	496..579	CDD:289987	24/96 (25%)
		COG4087	<760..823	CDD:226572	41/62 (66%)
		Cation_ATPase_C	872..1044	CDD:279079	42/198 (21%)
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	313/1041 (30%)
		Cation_ATPase_N	29..102	CDD:214842	25/72 (35%)
		E1-E2_ATPase	123..354	CDD:278548	84/256 (33%)
		Cation_ATPase	416..509	CDD:289987	24/96 (25%)
		COG4087	<673..738	CDD:226572	41/64 (64%)
		Cation_ATPase_C	785..994	CDD:279079	42/200 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438596
Domainoid	1	1.000	67	1.000	Domainoid score	I532
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51342
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840