DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and atp7a

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001036185.1	Gene:	atp7a / 564924	ZFINID:	ZDB-GENE-060825-45	Length:	1482	Species:	Danio rerio

Alignment Length:	1121	Identity:	214/1121 - (19%)
Similarity:	367/1121 - (32%)	Gaps:	411/1121 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTPKPLTSKRRTSP-------------ASPGSTVL------IESPTTSSGVRNRRSKIK---GVD 45
            |:|.|.......||             |.|.:..:      |...|.:|.|.|....:|   |:.
Zfish   438 KSPSPSVRSSSLSPVRSAVKENEAESDAEPSTNTISKCFIQIGGMTCASCVANIERNLKNEYGIH 502

  Fly    46 SKPNPQRTISHVKDSRA----VPQNVKPGKVADMKDCKE-----PDEDNVDQQNGN--IIQTGLT 99
            |      .:..:..|:|    .|..:.|.::|::  .:|     ...||.|..:|:  ::..|:|
Zfish   503 S------VLVALMASKAEVRYSPSVIDPLRIAEL--IRELGFTATVMDNYDGSDGSLELVVRGMT 559

  Fly   100 LTPEMLLSTSESSTH----SASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELL----------- 149
            ..         |..|    :..:..|.|...|.........||..::.|..:::
Zfish   560 CA---------SCVHKIESNLMKQKGILYASVALSTNKAHIKYDPEVTGPRDIIRLIENMGFTAS 615

  Fly   150 LVAED------------PTWKKYIE--------------------------------------QF 164
            ||.:|            ..||:..:                                      ::
Zfish   616 LVKKDRPGSHLDHSREIRQWKRSFQISLFFCVPVMGMMIYMIVVDHMIDKYHQHHNATAEDRAKY 680

  Fly   165 RNPLIL---LLLGSALVSVIMKQF---------------------DDAVSITIAILIVVTVAF-- 203
            .:.:.|   ||.|.:::::|...|                     ....::.:.|::..|:||
Zfish   681 HSTMFLEKQLLPGLSIMNLISFLFCVPVQFIGGRYFYCQAYKAVKHRTANMDVLIVLATTIAFTY 745

  Fly   204 ------------------------------------IQEYRSEKSLEELKKLVP----------- 221
                                                :::....|:.|.|.||:.
Zfish   746 SVVVLLVAMVERAKVNPITFFDTPPMLFVFISLGRWLEQIAKSKTSEALSKLMSLQATEATVVTL 810

  Fly   222 -PECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD 285
             .:...|.|.::|..|.:.   ||:|.:..|.:.|.|.|:.|...:: |||..|||..|..|..
Zfish   811 NEDMSVLSEEQVDVELVQR---GDVVKVVPGGKFPVDGRVIEGHSMA-DESLITGEAMPVTKKP- 870

  Fly   286 VLLNNTNVKDHSNMKNIAFMGTLVRCG----NGKGIVVST--GERSEFGEVFKMMQAEEAPKTPL 344
                                |:.|..|    ||..::.:|  |..:...::.|:::..:..|.|:
Zfish   871 --------------------GSTVIAGSINQNGSLLIKATHVGTDTTLSQIVKLVEEAQTSKAPI 915

  Fly   345 QKSMDILGAQLSFYSFL-IIGVIMLLGWL----------------QGKPLSE-------MFNISV 385
            |:..|.:.:.  |..|: :|.|:.||.|:                ..|.:||       .|..|:
Zfish   916 QQFADKISSY--FVPFIVVISVLTLLAWIIIGFVNFSLVQTYFPGYDKSISEAEAVIRFAFQASI 978

  Fly   386 SLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKN-EMTAT 449
            ::...|.|..|.:.....:.:|....|:...::|....:|....:..:..|||||:|.. .....
Zfish   979 TVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKIQSVVFDKTGTITYGAPKVVQ 1043

  Fly   450 IIITSDG------YMADVTGAGYNDQ----GEIHIRHCNNVEMAKTNITNLLEIGAV--CN-NAY 501
            :.:.::|      .:..:.|...|..    |....::|.. |:...::....:..||  |. ...
Zfish  1044 VKMLAEGNRLPRSKLLAIVGTAENSSEHPLGAAITKYCKQ-ELGTESLGTCTDFQAVPGCGIRCL 1107

  Fly   502 IQNGTLLGQPTEGALVAVAMKNGMYATAENY---VRIQ---------EYPFSSEQKMMAVKCIHK 554
            :.|       ||..|     |.....:.||.   |.||         |:|...:.:.:.|.....
Zfish  1108 VSN-------TENLL-----KREDSDSEENQHNAVLIQISDARAHSTEHPLIMDPQPLTVVQTAS 1160

  Fly   555 YN---NNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKG 616
            |.   .|:|  :..:.||                     |..|:......|..|:|...:.:|..
Zfish  1161 YTVLIGNRE--WMRRNAL---------------------QVRADVDEAMTEHERRGCTAVLVAVD 1202

  Fly   617 RSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIP 681
            ..:     |.:|.|.|..:|....::.:|...|:.|.::|||..:||.||
Zfish  1203 NEL-----CAMVAIADTVKPEAELAVHVLSAMGLEVVLMTGDNSKTARAI--------------- 1247

  Fly   682 AWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQM 746
                                             .||.|:.
Zfish  1248 ---------------------------------AAQVGIR------------------------- 1254

  Fly   747 NEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTD 811
                        .||..|.|.||:..|:.||::|..|.|.||||||..||..||:|||:| .|||
Zfish  1255 ------------KVFAEVLPSHKVAKVEQLQQAGKRVAMVGDGVNDSPALAMADVGIAIG-TGTD 1306

  Fly   812 VCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR-NFVRFQLSTSIAALALIALATLMDIANPLN- 874
            |..||||::|:.:|...::.:|:..|.....|| ||| |.|..::..:. ||....|.:...|.
Zfish  1307 VAIEAADVVLIRNDLLDVVGSIDLSKKTVKRIRINFV-FALMYNLVGIP-IAAGVFMPVGLVLQP 1369

  Fly   875 -----AMQILWINIIM 885
                 ||.:..:::::
Zfish  1370 WMGSAAMALSSVSVVL 1385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	187/981 (19%)
		Cation_ATPase_N	112..179	CDD:279080	16/134 (12%)
		E1-E2_ATPase	191..425	CDD:278548	59/313 (19%)
		Cation_ATPase	496..579	CDD:289987	20/100 (20%)
		COG4087	<760..823	CDD:226572	35/62 (56%)
		Cation_ATPase_C	872..1044	CDD:279079	3/20 (15%)
atp7a	NP_001036185.1	HMA	11..74	CDD:238219
		HMA	174..237	CDD:238219
		HMA	279..336	CDD:238219
		HMA	362..424	CDD:238219
		HMA	477..539	CDD:238219	14/69 (20%)
		ZntA	550..1377	CDD:225127	188/991 (19%)
		HMA	552..615	CDD:238219	10/71 (14%)
		E1-E2_ATPase	771..1018	CDD:278548	55/273 (20%)
		HAD_like	1171..1324	CDD:304363	62/264 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930