DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPoCk and atp2b1b

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001129103.1	Gene:	atp2b1b / 561190	ZFINID:	ZDB-GENE-080409-1	Length:	1240	Species:	Danio rerio

Alignment Length:	987	Identity:	267/987 - (27%)
Similarity:	425/987 - (43%)	Gaps:	267/987 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 DAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECH--CLREGRLDTFLARELVPGDIVHLN 249
            :..:|.::::.||.|....::..||....|:..:..|..  .||.|::......|:|.|||..:.
Zfish   150 EGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQRFTVLRGGQVIQIPVSEIVVGDIAQVK 214

  Fly   250 VGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRC 311
            .||.:|||..|.:..||.|||||.|||::..:|..|   :||:.|:|.:
Zfish   215 YGDLLPADGVLIQGNDLKIDESSLTGESDHVKKTLDKDPILLSGTHVME---------------- 263

  Fly   312 GNGKGIVVSTGERSEFGEVF-----------------------------KMMQAEEAPK------ 341
            |:||.:|.:.|..|:.|.:|                             |..:.||..|
Zfish   264 GSGKMLVTAVGVNSQTGIIFMLLGGGDDDDDDDEEKKEERERKKREKEEKRREKEEKKKEKERKK 328

  Fly   342 -----------------TPL----------------QKSMDIL--------------GAQLSFYS 359
                             .||                :|...:|              |..:|..:
Zfish   329 KEQKDKKKKKDGGTVEMEPLNSDDGTEEEQKKAKIPKKEKSVLQGKLTKLAVQIGKAGLFMSAIT 393

  Fly   360 FLIIGVIMLLG--WLQGKP------------LSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMR 410
            .||:.|:.|:.  |:||.|            ..:.|.|.|::.|.|:|||||:.||::||..|.:
Zfish   394 VLILVVLFLVDTFWIQGLPWIKDCTPIYIQFFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKK 458

  Fly   411 MAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIR 475
            |.|.|::|:.|...||:|....||||||||||.|.||...:.        :.|.        |.:
Zfish   459 MMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQVF--------IAGR--------HFK 507

  Fly   476 HCNNVEMAKTNITNLLEIGAVCNNAYI-------QNGTL---LGQPTEGALVAVAMKNGMYAT-- 528
            .....::...||.|||..|...|.||.       :.|.|   :|..||.||:.       :.|
Zfish   508 KVPEPDLIPGNIMNLLVTGIGVNCAYTSKIMSAEKEGGLPRQVGNKTECALLG-------FVTDL 565

  Fly   529 AENYVRIQ-EYP---------FSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGT 583
            .::|..|: |||         |:|.:|.|:.  :.| |::.....|:|||.|.||.:|.|.
Zfish   566 RKDYQAIRCEYPEEKLYKVYTFNSVRKSMST--VLK-NSDGSYRMFSKGASEILLKKCCKI---- 623

  Fly   584 QTVPLTKQNEA---------EFLAEAYE-IGRKGLRVLALA---------------KGRSMQDLI 623
                ||...:|         :.:.:..| :..:|||.:.||               :|..:..|.
Zfish   624 ----LTSNGDAKHFRPTDRDDMVTQVIEPMASEGLRTICLAYRDFLVSDGEPDWNNEGDILTGLT 684

  Fly   624 YCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGG 688
            ...:|||.||.||.|.::|:...::|:.|:|||||...||.||
Zfish   685 CICVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAI---------------------- 727

  Fly   689 VPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDK 753
                      :|.|                |:..:..:.:.::..........|:.::.:.:|||
Zfish   728 ----------ATKC----------------GILHIGDDFLCLEGKEFNRRIRNELGEIEQERLDK 766

  Fly   754 VANNVSVFYRVSPRHKLEIVKSL-------QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTD 811
            |...:.|..|.||..|..:||.:       ||  .:|.:||||.|||.||||||:|.|||..|||
Zfish   767 VWPKLRVLARSSPTDKHTLVKGIIDSTVLEQR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTD 829

  Fly   812 VCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAM 876
            |.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.|:.:......:...:||.|:
Zfish   830 VAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAV 894

  Fly   877 QILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQ 939
            |:||:|:|||...:.:|..||....:|.:||....:|:|:::::.|:|..|  .:.::.||....
Zfish   895 QMLWVNLIMDTFASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVYQLTIIFTLLFAG 959

  Fly   940 REMADGTLGKT-------KRDTTMTFTCFVFFDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVA 995
            .::.|...|:.       ....|:.|..||...:||.::.|.  ..::||. |:..|.:|...:.
Zfish   960 EQIFDIDSGRNAPLHAPPSEHYTVVFNTFVLMQLFNEINARKIHGERNVFE-GIFNNIIFCSILF 1023

  Fly   996 FSIIGQMLVVYF 1007
            .:.|.|.::|.|
Zfish  1024 GTFIIQFVIVQF 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	267/987 (27%)
		Cation_ATPase_N	112..179	CDD:279080
		E1-E2_ATPase	191..425	CDD:278548	84/334 (25%)
		Cation_ATPase	496..579	CDD:289987	30/104 (29%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	41/147 (28%)
atp2b1b	NP_001129103.1	ATPase-IIB_Ca	12..1073	CDD:273668	267/987 (27%)
		Cation_ATPase_N	45..115	CDD:279080
		E1-E2_ATPase	190..473	CDD:278548	76/298 (26%)
		Cation_ATPase	534..623	CDD:289987	27/98 (28%)
		HAD	<696..815	CDD:289480	41/168 (24%)
		Cation_ATPase_C	889..1067	CDD:279079	41/148 (28%)
		ATP_Ca_trans_C	1114..1163	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940