DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and atp2b3b

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_021325490.1	Gene:	atp2b3b / 558525	ZFINID:	ZDB-GENE-080409-2	Length:	1297	Species:	Danio rerio

Alignment Length:	1078	Identity:	280/1078 - (25%)
Similarity:	462/1078 - (42%)	Gaps:	271/1078 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EMLLSTSESSTHSASEVAG---RLQVDVRTGL--KWTEAKYRAKIIGHNELLLVAEDP-TWKKYI 161
            |.|....||.|    :|.|   ||:.....||  ..|:.:.|.:..|.|  .:..:.| |:.:.:
Zfish    51 EALQKIQESFT----DVEGLCQRLKSSTTDGLSDNPTDLEKRRQTFGQN--FIPPKKPKTFLQLV 109

  Fly   162 -EQFRNPLILLLLGSALVSVIMKQFD---------------------------DAVSITIAILIV 198
             |..::..:::|..:|::|:.:..:.                           :..:|.::::.|
Zfish   110 WEALQDVTLIILELAAIISLALSFYQPPGEDSEVCGKGAGGAEDEGEAEAGWIEGAAILLSVICV 174

  Fly   199 VTVAFIQEYRSEKSLEELKKLVPPECH--CLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLF 261
            |.|....::..||....|:..:..|..  .:|.|.:......|:|.||:..:..||.:|||..|.
Zfish   175 VLVTAFNDWSKEKQFRGLQSRIELEQRFAVVRNGNVIQIPVAEMVVGDMAQVKYGDLLPADGVLV 239

  Fly   262 EAVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMG---------TLVRCGNG 314
            :..||.|||||.|||::..||..:   :||:.|:|.:.|....:..:|         ||:..|.|
Zfish   240 QGNDLKIDESSLTGESDHVRKSVEKDPMLLSGTHVMEGSGRMLVTAVGVNSQSGIIFTLLGAGEG 304

  Fly   315 -------KG----IVVSTGER------------------SEFGEV----FKMMQAEEAPKTPLQK 346
                   ||    ..|.|.:.                  :|.|||    .|.....:..|:.||.
Zfish   305 EEEKKEKKGKQPEAAVETNQNKAKKQDGAVAMEMQPLKSAEGGEVEEREKKKANVPKKEKSVLQG 369

  Fly   347 SMDILGAQLSFYSFLI--IGVIML-------------LGWL-QGKPL-----SEMFNISVSLAVA 390
            .:..|..|:.....::  |.||:|             :.|| :..|:     .:.|.|.|::.|.
Zfish   370 KLTKLAVQIGKAGLVMSAITVIILVLYFVIDTFVVGNMTWLPECTPIYVQYFVKFFIIGVTVLVV 434

  Fly   391 AIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSD 455
            |:|||||:.||::||..|.:|.|.|::|:.|...||:|....||||||||||.|.||
Zfish   435 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMT-------- 491

  Fly   456 GYMADVTGAGYNDQGEIHIRHC--------NNVEMAKTNITNLLEIGAVCNNAY--------IQN 504
                 |..:..|||   |.|..        |.:||    |.|.:.|    |.||        ::.
Zfish   492 -----VVQSYINDQ---HFREIPDPSQISPNTLEM----IVNAISI----NCAYTSKIMPPDVEG 540

  Fly   505 G--TLLGQPTEGALVAVAMKNGMYATAENYVRIQE----------YPFSSEQKMMAVKCIHKYNN 557
            |  ..:|..||..|:...:.     ...:|..::|          |.|:|.:|.|:.  :.:..:
Zfish   541 GLPKQVGNKTECGLLGFLLD-----LKRDYAPVREQIPEEKLYKVYTFNSVRKSMST--VVQMPD 598

  Fly   558 NKEEIFFAKGALETLLPQCTKYQFGT--QTVPLTKQNEAEFLAEAYE-IGRKGLRVLALA----- 614
            ....: ::|||.|.:|.:|:.. .||  :......::..|.:.:..| :..:|||.:.:.
Zfish   599 GSFRL-YSKGASEIVLKKCSSI-LGTNGEARNFRPRDRDEMVKKVIEPMACEGLRTICIGYRDLP 661

  Fly   615 ---------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSR 670
                     :...:.||....:|||.||.||.|.::|....::|:.|:|||||...||.||
Zfish   662 GDPEPEWENEAEIVTDLTCIAVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAI---- 722

  Fly   671 RLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHH 735
                                   ||.|                .:.|.|...:
Zfish   723 -----------------------ASKC----------------GIIQPGDDFL------------ 736

  Fly   736 QTLSGQ--------EMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL-------QRSGNIVGM 785
             .|.|:        |..::.:.::||:...:.|..|.||..|..:||.:       ||  .:|.:
Zfish   737 -CLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVLEQR--QVVAV 798

  Fly   786 TGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQ 850
            ||||.|||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::||
Zfish   799 TGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQ 863

  Fly   851 LSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMI 915
            |:.::.|:.:......:...:||.|:|:||:|:|||...:.:|..||....:|.:||.....|:|
Zfish   864 LTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTEALLLRKPYGRNNPLI 928

  Fly   916 TKSVVVNVL---LSASIIVLGTLWVFQR--EMADGTLGK----TKRDTTMTFTCFVFFDMFNALS 971
            :.:::.|:|   :...:|:...|:|.::  .:..|...:    .....|:.|..||...:||.::
Zfish   929 SLTMMKNILGHGVYQLVIIFTLLFVGEKIFNIDSGRYAQLHSPPSEHYTIIFNTFVLMQLFNEIN 993

  Fly   972 CRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF 1007
            .|.  ..::||. |:..|.:|...|..:...|:::|.|
Zfish   994 ARKIHGERNVFD-GIFANPIFCSIVLGTFGVQVVIVQF 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	278/1071 (26%)
		Cation_ATPase_N	112..179	CDD:279080	16/73 (22%)
		E1-E2_ATPase	191..425	CDD:278548	83/301 (28%)
		Cation_ATPase	496..579	CDD:289987	21/102 (21%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	40/147 (27%)
atp2b3b	XP_021325490.1	E1-E2_ATPase	27..1068	CDD:332568	280/1078 (26%)
atp2b3b	XP_021325490.1	ATP_Ca_trans_C	1107..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940