DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and ATP7A

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_000043.4	Gene:	ATP7A / 538	HGNCID:	869	Length:	1500	Species:	Homo sapiens

Alignment Length:	835	Identity:	174/835 - (20%)
Similarity:	302/835 - (36%)	Gaps:	267/835 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 WKKYIEQFR-------NPLILLLLGS------ALVSVIMKQFDDAVSITIAI-----LIVVTVA- 202
            |..||:.::       |..:|::|.:      :|:.:::..::.|....|..     ::.|.:|
Human   729 WYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIAL 793

  Fly   203 --FIQEYRSEKSLEELKKLVPPECH------------CLREGRLDTFLARELVPGDIVHLNVGDR 253
              :::.....|:.|.|.||:..:..            .|.|.::|..|.:.   |||:.:..|.:
Human   794 GRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQR---GDIIKVVPGGK 855

  Fly   254 VPADVRLFEAVDLSIDESSFTGETEPARKI--TDVLLNNTNVKDHSNMKNIAFMGTLVRCGNGKG 316
            .|.|.|:.|...: :|||..|||..|..|.  :.|:..:.|..           |:|:.|
Human   856 FPVDGRVIEGHSM-VDESLITGEAMPVAKKPGSTVIAGSINQN-----------GSLLIC----- 903

  Fly   317 IVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLI-IGVIMLLGWL-------- 372
             ....|..:...::.|:::..:..|.|:|:..|.|...  |..|:: :.:..||.|:
Human   904 -ATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGY--FVPFIVFVSIATLLVWIVIGFLNFE 965

  Fly   373 --------QGKPLSE-------MFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLP 422
                    ..:.:|.       .|..|:::...|.|..|.:.....:.:|....|:...::|...
Human   966 IVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGE 1030

  Fly   423 TVETLGCVNVICSDKTGTLTKNE--------MTATIIITSDGYMADVTGAGYNDQ---GEIHIRH 476
            .:|....|.|:..|||||:|...        :|.:..|:....:|.|..|..|.:   |....::
Human  1031 PLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKY 1095

  Fly   477 CN--------------------NVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAVAM 521
            |.                    .:....|||..||.    .||..|::..:    ...:||.:..
Human  1096 CKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLH----KNNWNIEDNNI----KNASLVQIDA 1152

  Fly   522 KNGMYATA---------ENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCT 577
            .|...:|:         .|.:..|:|      |::.        .|:|  :..:..|
Human  1153 SNEQSSTSSSMIIDAQISNALNAQQY------KVLI--------GNRE--WMIRNGL-------- 1193

  Fly   578 KYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGITDPPRPLVRESI 642
                      :...:..:|:.|....||..:.|       ::.|.: |||:.|.|..:|....:|
Human  1194 ----------VINNDVNDFMTEHERKGRTAVLV-------AVDDEL-CGLIAIADTVKPEAELAI 1240

  Fly   643 EMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAM 707
            .:|...|:.|.::|||..:||.:|
Human  1241 HILKSMGLEVVLMTGDNSKTARSI----------------------------------------- 1264

  Fly   708 KEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEI 772
                             |:.:||                           ..||..|.|.||:..
Human  1265 -----------------ASQVGI---------------------------TKVFAEVLPSHKVAK 1285

  Fly   773 VKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGK 837
            ||.||..|..|.|.|||:||..||..|::|||:| .||||..||||::|:.:|...::|:|:..:
Human  1286 VKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSR 1349

  Fly   838 GIFYNIR-NFVRFQLSTSIAALALIALATLMDIANPLN------AMQILWINIIM 885
            .....|| ||| |.|..::..:. ||....|.|...|.      ||....:::::
Human  1350 KTVKRIRINFV-FALIYNLVGIP-IAAGVFMPIGLVLQPWMGSAAMAASSVSVVL 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	174/835 (21%)
		Cation_ATPase_N	112..179	CDD:279080	7/34 (21%)
		E1-E2_ATPase	191..425	CDD:278548	54/279 (19%)
		Cation_ATPase	496..579	CDD:289987	14/91 (15%)
		COG4087	<760..823	CDD:226572	34/62 (55%)
		Cation_ATPase_C	872..1044	CDD:279079	3/20 (15%)
ATP7A	NP_000043.4	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..443	CDD:238219
		HMA	492..554	CDD:238219
		HMA	567..630	CDD:238219
		P-type_ATPase_Cu-like	652..1388	CDD:319783	172/819 (21%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1467..1468
		PDZD11-binding	1486..1500
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1487..1488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840