DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2a3

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_058025.2	Gene:	Atp2a3 / 53313	MGIID:	1194503	Length:	1038	Species:	Mus musculus

Alignment Length:	1057	Identity:	329/1057 - (31%)
Similarity:	523/1057 - (49%)	Gaps:	190/1057 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ESSTHSASEVAGRLQVDVRTGL---KWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILL 171
            |:...||::|..|..|....||   :.|:|:.|   .|.|||........|:..:|||.:.|:.:
Mouse     3 EAHLLSAADVLRRFSVTAEGGLSLEQVTDARER---YGPNELPTEEGKSLWELVVEQFEDLLVRI 64

  Fly   172 LLGSALVSVIMKQFDDAVSITIA-------ILIVVTVAFI---QEYRSEKSLEELKKLVPPECHC 226
            ||.:||||.::..|::....|.|       :||:|..|.:   ||..:|.::|.||:..|.....
Mouse    65 LLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKV 129

  Fly   227 LREGR--LDTFLARELVPGDIVHLNVGDRVPADVRLFE--AVDLSIDESSFTGETEPARKITDVL 287
            :|..|  :....||::||||||.:.|||:||||:||.|  :..|.:|:|..|||:....|.||.:
Mouse   130 IRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAI 194

  Fly   288 LNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILG 352
            .:...|  :.:.||:.|.||.:..|...|:.|:||.::|.|::...|.|.|..:||||:.:|..|
Mouse   195 PDPRAV--NQDKKNMLFSGTNIASGKALGVAVATGLQTELGKIRSQMAAVEPERTPLQRKLDEFG 257

  Fly   353 AQLSFYSFLIIGVIMLL------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLA 405
            .|||....:|...:.::            .||:|...  .|.|:|:|||||||||||.|:|..||
Mouse   258 RQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVY--YFKIAVALAVAAIPEGLPAVITTCLA 320

  Fly   406 LGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT---IIITSDG-----YMADVT 462
            ||..|||::|:||:.||:||||||.:|||||||||||.|:|:..   ::..::.     :...::
Mouse   321 LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGTCRLHEFTIS 385

  Fly   463 GAGYNDQGEIH-----IRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTL------LGQPTEGAL 516
            |..|..:||:.     :| |...:    .:..|..|.|:||::.:.....      :|:.||.||
Mouse   386 GTTYTPEGEVRQGEQPVR-CGQFD----GLVELATICALCNDSALDYNEAKGVYEKVGEATETAL 445

  Fly   517 VAVAMKNGMYAT-AENYVRIQE-----------------YPFSSEQKMMAVKCI-----HKYNNN 558
            ..:..|..::.| .:...|::.                 ..||.::|.|:|.|.     .|...:
Mouse   446 TCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKVQGS 510

  Fly   559 KEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEA--YEIGRKGLRVLALAK------ 615
            |   .|.|||.|:::.:|:..:.|::|.||:..:....||:.  :..|...||.||||.
Mouse   511 K---MFVKGAPESVIERCSSVRVGSRTAPLSTTSREHILAKIRDWGSGSDTLRCLALATRDTPPR 572

  Fly   616 ---------GRSMQ---DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDP 668
                     .|.:|   ||.:.|.||:.|||||.|...|....::|:||.|:|||.:.||:||
Mouse   573 KEDMHLDDCSRFVQYETDLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAI-- 635

  Fly   669 SRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTI 733
            .|||                                              |:...|.:::|
Mouse   636 CRRL----------------------------------------------GIFGDTEDVLG---- 650

  Fly   734 HHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKK 798
              :..:|:|.|.::..|..:.......|.||.|.||..||::||....|..||||||||..||||
Mouse   651 --KAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKK 713

  Fly   799 ADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIAL 863
            |:|||||| :||.|.|.||:|:|.:|:|.:|:||:|||:.|:.|::.|:|:.:|:::..:..|.|
Mouse   714 AEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFL 777

  Fly   864 ATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNV 923
            ..::.:...|..:|:||:|::.||.||.:||..|.|.|::::.|||.::.:|:     :.:.:.|
Mouse   778 TAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRNPREALISGWLFFRYLAIGV 842

  Fly   924 LLSASIIVLGTLWV----------------FQREMADGTL--------GKTKRDTTMTFTCFVFF 964
            .:..:.:...|.|.                |.:...|..|        .:::..|||..:..|..
Mouse   843 YVGLATVAAATWWFLYDTEGPQVTFYQLRNFLKCSEDNPLFAGIDCKVFESRFPTTMALSVLVTI 907

  Fly   965 DMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVS 1029
            :|.|||:..|:.:|:..:....|...|.||..|:....|::..|||.::||...|:......::.
Mouse   908 EMCNALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQ 972

  Fly  1030 LTSSVLVVSEIKKWFER 1046
            ::..|:::.|..|:..|
Mouse   973 MSLPVILLDEALKYLSR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	329/1057 (31%)
		Cation_ATPase_N	112..179	CDD:279080	23/69 (33%)
		E1-E2_ATPase	191..425	CDD:278548	99/259 (38%)
		Cation_ATPase	496..579	CDD:289987	24/111 (22%)
		COG4087	<760..823	CDD:226572	38/62 (61%)
		Cation_ATPase_C	872..1044	CDD:279079	49/200 (25%)
Atp2a3	NP_058025.2	Cation_ATPase_N	4..72	CDD:279080	23/70 (33%)
		ATPase-IIA1_Ca	53..989	CDD:273452	312/1002 (31%)
		E1-E2_ATPase	92..340	CDD:278548	97/251 (39%)
		Interaction with phospholamban 1. /evidence=ECO:0000250\|UniProtKB:P04191	370..400		4/29 (14%)
		Cation_ATPase	419..528	CDD:289987	24/111 (22%)
		HAD	<604..712	CDD:289480	45/161 (28%)
		Cation_ATPase_C	784..987	CDD:279079	49/202 (24%)
		Interaction with phospholamban 2. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730