DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and atp2a1l

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_005156129.1	Gene:	atp2a1l / 494489	ZFINID:	ZDB-GENE-041229-2	Length:	993	Species:	Danio rerio

Alignment Length:	1053	Identity:	326/1053 - (30%)
Similarity:	509/1053 - (48%)	Gaps:	185/1053 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLG 174
            ::.|...:|......|...|||...:.|......|:|||........|:..||||.:.|:.:||.
Zfish     3 DAHTKGPAECLAYFSVSETTGLSPEQFKKNLAKYGYNELPAEEGKSIWELIIEQFEDLLVRILLL 67

  Fly   175 SALVSVIMKQFDDA-------VSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLRE 229
            :|.:|.::..|::.       |...:.:||::..|.:   ||..:|.::|.||:..|......|.
Zfish    68 AACISFVLAWFEEGEETITAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVYRS 132

  Fly   230 GR--LDTFLARELVPGDIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNN 290
            .|  :....|||:||||||.::|||:||||:|:  ..:..|.:|:|..|||:....|.|:.:.:.
Zfish   133 DRKSVQMIKAREIVPGDIVEVSVGDKVPADIRITHIRSTTLRVDQSILTGESVSVIKHTEPVPDP 197

  Fly   291 TNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQL 355
            ..|  :.:.||:.|.||.:..|...|:.|:||..:|.|::...|.|.|..|||||:.:|..|.||
Zfish   198 RAV--NQDKKNMLFSGTNIAAGKAVGVAVATGVATEIGKIRDQMAATEQEKTPLQQKLDEFGEQL 260

  Fly   356 S-FYSFLIIGVIML-LG----------WLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGV 408
            | ..|.:.:.|.|: :|          |::|...  .|.|:|:|||||||||||.|:|..||||.
Zfish   261 SKVISLICVAVWMINIGHFNDPVHGGSWIRGAVY--YFKIAVALAVAAIPEGLPAVITTCLALGT 323

  Fly   409 MRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT---IIITSDGYMA-----DVTGAG 465
            .||||:|:||:.||:||||||.:|||||||||||.|:|..|   :|...||...     |::|:.
Zfish   324 RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMCVTKMFVIDRIDGDHVELDSFDISGSK 388

  Fly   466 YNDQGEIHIR----HCNNVEMAKTNITNLLEIGAVCNNAYIQ-NGT-----LLGQPTEGALVAVA 520
            |..:||:...    .|:..:    .:..|..|.|:||::.:. |.|     .:|:.||.||..:.
Zfish   389 YTPEGEVTKLGAKVDCSQYD----GLVELATICALCNDSSLDYNETKKIYEKVGEATETALCCLV 449

  Fly   521 MKNGMY-ATAENYVRIQE-----------------YPFSSEQKMMAVKCIHKYNNNKEEIFFAKG 567
            .|..:: :...|..:::.                 ..||.::|.|:|.|. ....:.....|.||
Zfish   450 EKMNVFKSNVGNLSKVERANACCSVVKQLMKKNFTLEFSRDRKSMSVYCT-PVKGDAGSKMFVKG 513

  Fly   568 ALETLLPQCTKYQFGTQTVPLT---KQNEAEFLAEAYEIGRKGLRVLALA------KGRSMQ--- 620
            |.|.::.:||..:.|:..||||   |......:.| :..||..||.||||      |...|.
Zfish   514 APEGVIDRCTYVRVGSTRVPLTGAVKDKIMNVIKE-WGTGRDTLRCLALATRDSPLKVEEMNLED 577

  Fly   621 ---------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVP 676
                     ||.:.|.||:.||||..|..|||:...:|:||.|:|||.:.||:||  .||
Zfish   578 STKFADYETDLTFVGCVGMLDPPRKEVTGSIELCRAAGIRVIMITGDNKGTAVAI--CRR----- 635

  Fly   677 THAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGI----DTIHHQT 737
                                                               |||    :.:..:.
Zfish   636 ---------------------------------------------------IGIFSEDEDVTGKA 649

  Fly   738 LSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIG 802
            .:|:|.|.:...:..:.......|.||.|.||.:||:.||....|..||||||||..|||||:||
Zfish   650 YTGREFDDLPHSEQSEAVRRACCFARVEPSHKSKIVEFLQGYDEITAMTGDGVNDAPALKKAEIG 714

  Fly   803 IAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLM 867
            |||| :||.|.|.|::|:|.:|:|.:|:||:|||:.|:.|::.|:|:.:|::|..:..|.|...:
Zfish   715 IAMG-SGTAVAKSASEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVCIFLTAAL 778

  Fly   868 DIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSA 927
            .:...|..:|:||:|::.||.||.:||..|.|.:::.:.||:.|:|:|:     :.:.|...:.|
Zfish   779 GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLEIMGKPPRSPKEPLISGWLFFRYMTVGAYVGA 843

  Fly   928 SIIVLGTLW-VFQREMADGTLGKTKR-----------------------DTTMTFTCFVFFDMFN 968
            :.:.....| ::..|....|..:...                       ..||..:..|..:|.|
Zfish   844 ATVAAAAYWFIYDEEGPQVTYYQLSHFMQCHEENEDFTGIECEVFEACPPMTMALSVLVTIEMCN 908

  Fly   969 ALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSS 1033
            ||:..|:.:|:..:...:|...|.|:..|:....:::|..|:.|:|:...|.....|.::.|:..
Zfish   909 ALNSLSENQSLVRMPPWSNGWLLSAMTLSMSLHFMIIYVDPMPMIFRLTHLNTEQWFVVLKLSFP 973

  Fly  1034 VLVVSEIKKWFER 1046
            |:::.|:.|:..|
Zfish   974 VILIDEMLKFLAR 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	326/1053 (31%)
		Cation_ATPase_N	112..179	CDD:279080	20/66 (30%)
		E1-E2_ATPase	191..425	CDD:278548	98/252 (39%)
		Cation_ATPase	496..579	CDD:289987	24/106 (23%)
		COG4087	<760..823	CDD:226572	37/62 (60%)
		Cation_ATPase_C	872..1044	CDD:279079	46/200 (23%)
atp2a1l	XP_005156129.1	Cation_ATPase_N	4..72	CDD:279080	20/67 (30%)
		ATPase-IIA1_Ca	53..986	CDD:273452	313/1001 (31%)
		E1-E2_ATPase	93..340	CDD:278548	98/250 (39%)
		Cation_ATPase	419..525	CDD:289987	24/106 (23%)
		HAD	<608..709	CDD:289480	41/158 (26%)
		Cation_ATPase_C	781..984	CDD:279079	46/202 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660